Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop

The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therape...

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Auteurs principaux: Benjamin M. Janus, Nydia van Dyk, Xuelian Zhao, Katie A. Howell, Cinque Soto, M. Javad Aman, Yuxing Li, Thomas R. Fuerst, Gilad Ofek
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c
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