Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

The adaptor protein p11 and K+ channel TASK1 have overlapping distributions in the CNS. Here, the authors demonstrate that the transcription factor Sp1 regulates p11 levels, which in turn affects intrinsic membrane properties and can contribute to degeneration of motor neurons in disease and injury...

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Autores principales:	Victoria García-Morales, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, Germán Domínguez-Vías, David González-Forero, Federico Portillo, Antonio Campos-Caro, Ángela Gento-Caro, Noura Issaoui, Rosa M. Soler, Ana Garcera, Bernardo Moreno-López
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20e757cfad114f6fb6a76661d270846b
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spelling	oai:doaj.org-article:20e757cfad114f6fb6a76661d270846b2021-12-02T17:31:37ZSp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK110.1038/s41467-019-11637-42041-1723https://doaj.org/article/20e757cfad114f6fb6a76661d270846b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11637-4https://doaj.org/toc/2041-1723The adaptor protein p11 and K+ channel TASK1 have overlapping distributions in the CNS. Here, the authors demonstrate that the transcription factor Sp1 regulates p11 levels, which in turn affects intrinsic membrane properties and can contribute to degeneration of motor neurons in disease and injury models.Victoria García-MoralesGuillermo Rodríguez-BeyLaura Gómez-PérezGermán Domínguez-VíasDavid González-ForeroFederico PortilloAntonio Campos-CaroÁngela Gento-CaroNoura IssaouiRosa M. SolerAna GarceraBernardo Moreno-LópezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-23 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victoria García-Morales Guillermo Rodríguez-Bey Laura Gómez-Pérez Germán Domínguez-Vías David González-Forero Federico Portillo Antonio Campos-Caro Ángela Gento-Caro Noura Issaoui Rosa M. Soler Ana Garcera Bernardo Moreno-López Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
description	The adaptor protein p11 and K+ channel TASK1 have overlapping distributions in the CNS. Here, the authors demonstrate that the transcription factor Sp1 regulates p11 levels, which in turn affects intrinsic membrane properties and can contribute to degeneration of motor neurons in disease and injury models.
format	article
author	Victoria García-Morales Guillermo Rodríguez-Bey Laura Gómez-Pérez Germán Domínguez-Vías David González-Forero Federico Portillo Antonio Campos-Caro Ángela Gento-Caro Noura Issaoui Rosa M. Soler Ana Garcera Bernardo Moreno-López
author_facet	Victoria García-Morales Guillermo Rodríguez-Bey Laura Gómez-Pérez Germán Domínguez-Vías David González-Forero Federico Portillo Antonio Campos-Caro Ángela Gento-Caro Noura Issaoui Rosa M. Soler Ana Garcera Bernardo Moreno-López
author_sort	Victoria García-Morales
title	Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
title_short	Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
title_full	Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
title_fullStr	Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
title_full_unstemmed	Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
title_sort	sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of task1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/20e757cfad114f6fb6a76661d270846b
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Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

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