The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis

Although many efforts have been made to explore the genetic basis of divergent thinking (DT), there is still a gap in the understanding of how these findings relate to the neurobiology of DT. In a combined sample of 1,682 Chinese participants, by integrating GWAS with previously identified brain-spe...

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Autores principales:	Shun Zhang, Xiaolei Yang, Si Si, Jinghuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Divergent thinking Creativity Genetics GWAS Gene co-expression network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/20e75b7cf5704e95817e25d69a643751
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spelling	oai:doaj.org-article:20e75b7cf5704e95817e25d69a6437512021-12-04T04:33:18ZThe neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis1095-957210.1016/j.neuroimage.2021.118762https://doaj.org/article/20e75b7cf5704e95817e25d69a6437512021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S105381192101034Xhttps://doaj.org/toc/1095-9572Although many efforts have been made to explore the genetic basis of divergent thinking (DT), there is still a gap in the understanding of how these findings relate to the neurobiology of DT. In a combined sample of 1,682 Chinese participants, by integrating GWAS with previously identified brain-specific gene co-expression network modules, this study explored for the first time the functional brain-specific gene co-expression networks underlying DT. The results showed that gene co-expression network modules in anterior cingulate cortex, caudate, amygdala and substantia nigra were enriched with DT association signals. Further functional enrichment analysis showed that these DT-related gene co-expression network modules were enriched for key biological process and cellular component related to myelination, suggesting that cortical and sub-cortical grey matter myelination may serve as important neurobiological basis of DT. Although the underlying mechanisms need to be further refined, this exploratory study may provide new insight into the neurobiology of DT.Shun ZhangXiaolei YangSi SiJinghuan ZhangElsevierarticleDivergent thinkingCreativityGeneticsGWASGene co-expression networkNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118762- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Divergent thinking Creativity Genetics GWAS Gene co-expression network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Divergent thinking Creativity Genetics GWAS Gene co-expression network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Shun Zhang Xiaolei Yang Si Si Jinghuan Zhang The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
description	Although many efforts have been made to explore the genetic basis of divergent thinking (DT), there is still a gap in the understanding of how these findings relate to the neurobiology of DT. In a combined sample of 1,682 Chinese participants, by integrating GWAS with previously identified brain-specific gene co-expression network modules, this study explored for the first time the functional brain-specific gene co-expression networks underlying DT. The results showed that gene co-expression network modules in anterior cingulate cortex, caudate, amygdala and substantia nigra were enriched with DT association signals. Further functional enrichment analysis showed that these DT-related gene co-expression network modules were enriched for key biological process and cellular component related to myelination, suggesting that cortical and sub-cortical grey matter myelination may serve as important neurobiological basis of DT. Although the underlying mechanisms need to be further refined, this exploratory study may provide new insight into the neurobiology of DT.
format	article
author	Shun Zhang Xiaolei Yang Si Si Jinghuan Zhang
author_facet	Shun Zhang Xiaolei Yang Si Si Jinghuan Zhang
author_sort	Shun Zhang
title	The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
title_short	The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
title_full	The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
title_fullStr	The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
title_full_unstemmed	The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis
title_sort	neurobiological basis of divergent thinking: insight from gene co-expression network-based analysis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/20e75b7cf5704e95817e25d69a643751
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The neurobiological basis of divergent thinking: Insight from gene co-expression network-based analysis

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