Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.

We have previously shown that invariant Vα19-Jα33 TCR(+) (Vα19i T) cells suppress the disease progress in some models for organ specific autoimmune diseases and type IV allergy that deteriorate along with decline to excess in Th1- or Th17- immunity. In this study, we examined the effects of over-gen...

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Autores principales:	Michio Shimamura, Yi-Ying Huang, Hiroshi Hidaka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20e876d704484c12bc20225af42cee97
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spelling	oai:doaj.org-article:20e876d704484c12bc20225af42cee972021-11-18T06:51:54ZModulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.1932-620310.1371/journal.pone.0020915https://doaj.org/article/20e876d704484c12bc20225af42cee972011-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0020804https://doaj.org/toc/1932-6203We have previously shown that invariant Vα19-Jα33 TCR(+) (Vα19i T) cells suppress the disease progress in some models for organ specific autoimmune diseases and type IV allergy that deteriorate along with decline to excess in Th1- or Th17- immunity. In this study, we examined the effects of over-generation of Vα19i T cells on the Th2-controlled immunoglobulin isotype production in the models for type I allergy. IgE production by invariant Vα19-Jα33 TCR transgenic (Tg) mice was suppressed compared with that by non-Tg controls following administration with goat anti-mouse IgD antiserum or OVA, while IgG2a production was not influenced by the introduction of the transgene into the recipients. IgE production by wild type mice was similarly reduced when they were subjected to adoptive transfer with invariant Vα19-Jα33 TCR Tg(+) but not Tg(-) cells prior to immunization. Furthermore, the suppression of IgE production by these recipients was enhanced when they were previously administered with a Vα19i T cell activator, one of the modified α-mannosyl ceramides. In summary, it is suggested that Vα19i T cells have potential to participate in the homeostasis of immunity and that they suppress disease progression resulting from not only Th1- but also Th2- immunity excess.Michio ShimamuraYi-Ying HuangHiroshi HidakaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20915 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michio Shimamura Yi-Ying Huang Hiroshi Hidaka Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
description	We have previously shown that invariant Vα19-Jα33 TCR(+) (Vα19i T) cells suppress the disease progress in some models for organ specific autoimmune diseases and type IV allergy that deteriorate along with decline to excess in Th1- or Th17- immunity. In this study, we examined the effects of over-generation of Vα19i T cells on the Th2-controlled immunoglobulin isotype production in the models for type I allergy. IgE production by invariant Vα19-Jα33 TCR transgenic (Tg) mice was suppressed compared with that by non-Tg controls following administration with goat anti-mouse IgD antiserum or OVA, while IgG2a production was not influenced by the introduction of the transgene into the recipients. IgE production by wild type mice was similarly reduced when they were subjected to adoptive transfer with invariant Vα19-Jα33 TCR Tg(+) but not Tg(-) cells prior to immunization. Furthermore, the suppression of IgE production by these recipients was enhanced when they were previously administered with a Vα19i T cell activator, one of the modified α-mannosyl ceramides. In summary, it is suggested that Vα19i T cells have potential to participate in the homeostasis of immunity and that they suppress disease progression resulting from not only Th1- but also Th2- immunity excess.
format	article
author	Michio Shimamura Yi-Ying Huang Hiroshi Hidaka
author_facet	Michio Shimamura Yi-Ying Huang Hiroshi Hidaka
author_sort	Michio Shimamura
title	Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
title_short	Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
title_full	Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
title_fullStr	Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
title_full_unstemmed	Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.
title_sort	modulation of immunoglobulin production by invariant vα19-jα33 tcr-bearing cells.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/20e876d704484c12bc20225af42cee97
work_keys_str_mv	AT michioshimamura modulationofimmunoglobulinproductionbyinvariantva19ja33tcrbearingcells AT yiyinghuang modulationofimmunoglobulinproductionbyinvariantva19ja33tcrbearingcells AT hiroshihidaka modulationofimmunoglobulinproductionbyinvariantva19ja33tcrbearingcells
_version_	1718424277470937088

Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells.

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