Full-length L1CAM and not its Δ2Δ27 splice variant promotes metastasis through induction of gelatinase expression.

Full-length L1CAM and not its Δ2Δ27 splice variant promotes metastasis through induction of gelatinase expression.

Tumour-specific splicing is known to contribute to cancer progression. In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2...

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Main Authors: Stephanie Hauser, Laura Bickel, Dirk Weinspach, Michael Gerg, Michael K Schäfer, Marco Pfeifer, John Hazin, Florian Schelter, Ulrich H Weidle, Juliane Ramser, Juliane Volkmann, Alfons Meindl, Manfred Schmitt, Florian Schrötzlmair, Peter Altevogt, Achim Krüger
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/20e94dbc38a8494ea8dea37e22a7e445
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https://doaj.org/article/20e94dbc38a8494ea8dea37e22a7e445

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