Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction.

Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction.

<h4>Background</h4>Nucleotide excision repair (NER) removes many types of DNA lesions including those induced by UV radiation and platinum-based therapy. Resistance to platinum-based therapy correlates with high expression of ERCC1, a major element of the NER machinery. The interaction b...

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Autores principales: Khaled H Barakat, Lars P Jordheim, Rolando Perez-Pineiro, David Wishart, Charles Dumontet, Jack A Tuszynski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/20ece2b4d4f641e686586a44680936bf
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