Reversible induction of mitophagy by an optogenetic bimodular system

Reversible induction of mitophagy by an optogenetic bimodular system

Autophagic degradation of mitochondria (mitophagy) is a key quality control mechanism in cellular homeostasis, and its misregulation is involved in neurodegenerative diseases. Here the authors develop an optogenetic system for reversible induction of mitophagy and validate its use in cell culture an...

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Autores principales: Pasquale D’Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula, Gerrit Weber, Francesca Del Bufalo, Luisa Dalla Valle, Silvia Campello, Franco Locatelli, Francesco Cecconi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/20ed3b924c8c43a6a43fe7c1750bfd88
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spelling oai:doaj.org-article:20ed3b924c8c43a6a43fe7c1750bfd882021-12-02T14:38:38ZReversible induction of mitophagy by an optogenetic bimodular system10.1038/s41467-019-09487-12041-1723https://doaj.org/article/20ed3b924c8c43a6a43fe7c1750bfd882019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09487-1https://doaj.org/toc/2041-1723Autophagic degradation of mitochondria (mitophagy) is a key quality control mechanism in cellular homeostasis, and its misregulation is involved in neurodegenerative diseases. Here the authors develop an optogenetic system for reversible induction of mitophagy and validate its use in cell culture and zebrafish embryos.Pasquale D’AcunzoFlavie StrappazzonIgnazio CaruanaGiacomo MeneghettiAnthea Di RitaLuca SimulaGerrit WeberFrancesca Del BufaloLuisa Dalla ValleSilvia CampelloFranco LocatelliFrancesco CecconiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pasquale D’Acunzo
Flavie Strappazzon
Ignazio Caruana
Giacomo Meneghetti
Anthea Di Rita
Luca Simula
Gerrit Weber
Francesca Del Bufalo
Luisa Dalla Valle
Silvia Campello
Franco Locatelli
Francesco Cecconi
Reversible induction of mitophagy by an optogenetic bimodular system
description Autophagic degradation of mitochondria (mitophagy) is a key quality control mechanism in cellular homeostasis, and its misregulation is involved in neurodegenerative diseases. Here the authors develop an optogenetic system for reversible induction of mitophagy and validate its use in cell culture and zebrafish embryos.
format article
author Pasquale D’Acunzo
Flavie Strappazzon
Ignazio Caruana
Giacomo Meneghetti
Anthea Di Rita
Luca Simula
Gerrit Weber
Francesca Del Bufalo
Luisa Dalla Valle
Silvia Campello
Franco Locatelli
Francesco Cecconi
author_facet Pasquale D’Acunzo
Flavie Strappazzon
Ignazio Caruana
Giacomo Meneghetti
Anthea Di Rita
Luca Simula
Gerrit Weber
Francesca Del Bufalo
Luisa Dalla Valle
Silvia Campello
Franco Locatelli
Francesco Cecconi
author_sort Pasquale D’Acunzo
title Reversible induction of mitophagy by an optogenetic bimodular system
title_short Reversible induction of mitophagy by an optogenetic bimodular system
title_full Reversible induction of mitophagy by an optogenetic bimodular system
title_fullStr Reversible induction of mitophagy by an optogenetic bimodular system
title_full_unstemmed Reversible induction of mitophagy by an optogenetic bimodular system
title_sort reversible induction of mitophagy by an optogenetic bimodular system
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/20ed3b924c8c43a6a43fe7c1750bfd88
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AT flaviestrappazzon reversibleinductionofmitophagybyanoptogeneticbimodularsystem
AT ignaziocaruana reversibleinductionofmitophagybyanoptogeneticbimodularsystem
AT giacomomeneghetti reversibleinductionofmitophagybyanoptogeneticbimodularsystem
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