Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour...

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Autores principales: Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q. Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/20f327dfca6c464ba7984c61c7778da5
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spelling oai:doaj.org-article:20f327dfca6c464ba7984c61c7778da52021-12-02T17:06:04ZBlockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells10.1038/ncomms152072041-1723https://doaj.org/article/20f327dfca6c464ba7984c61c7778da52017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15207https://doaj.org/toc/2041-1723Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour regression.Yuying LiuXiaoyu LiangXiaonan YinJiadi LvKe TangJingwei MaTiantian JiHuafeng ZhangWenqian DongXun JinDegao ChenYanchun LiSongyan ZhangHeidi Q. XieBin ZhaoTong ZhaoJinzhi LuZhuo-Wei HuXuetao CaoF. Xiao-Feng QinBo HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuying Liu
Xiaoyu Liang
Xiaonan Yin
Jiadi Lv
Ke Tang
Jingwei Ma
Tiantian Ji
Huafeng Zhang
Wenqian Dong
Xun Jin
Degao Chen
Yanchun Li
Songyan Zhang
Heidi Q. Xie
Bin Zhao
Tong Zhao
Jinzhi Lu
Zhuo-Wei Hu
Xuetao Cao
F. Xiao-Feng Qin
Bo Huang
Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
description Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour regression.
format article
author Yuying Liu
Xiaoyu Liang
Xiaonan Yin
Jiadi Lv
Ke Tang
Jingwei Ma
Tiantian Ji
Huafeng Zhang
Wenqian Dong
Xun Jin
Degao Chen
Yanchun Li
Songyan Zhang
Heidi Q. Xie
Bin Zhao
Tong Zhao
Jinzhi Lu
Zhuo-Wei Hu
Xuetao Cao
F. Xiao-Feng Qin
Bo Huang
author_facet Yuying Liu
Xiaoyu Liang
Xiaonan Yin
Jiadi Lv
Ke Tang
Jingwei Ma
Tiantian Ji
Huafeng Zhang
Wenqian Dong
Xun Jin
Degao Chen
Yanchun Li
Songyan Zhang
Heidi Q. Xie
Bin Zhao
Tong Zhao
Jinzhi Lu
Zhuo-Wei Hu
Xuetao Cao
F. Xiao-Feng Qin
Bo Huang
author_sort Yuying Liu
title Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
title_short Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
title_full Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
title_fullStr Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
title_full_unstemmed Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
title_sort blockade of ido-kynurenine-ahr metabolic circuitry abrogates ifn-γ-induced immunologic dormancy of tumor-repopulating cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/20f327dfca6c464ba7984c61c7778da5
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