Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
Tumour repopulating cells (TRC) are stem-like cells that can escape immune-mediated killing. Here, the authors show IFN-γ results in either dormancy or apoptosis of TRC depending on the activation of the IDO1 metabolic pathway, and that combining IFN-γ with IDO1 inhibitors results in enhanced tumour...
Guardado en:
Autores principales: | Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q. Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/20f327dfca6c464ba7984c61c7778da5 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Correction: Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway
por: Lisha Du, et al.
Publicado: (2021) -
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
por: Luis Felipe Campesato, et al.
Publicado: (2020) -
AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle
por: Young-Chae Kim, et al.
Publicado: (2018) -
Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
por: Fangyi Shi, et al.
Publicado: (2021) -
Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
por: Christopher Manzella, et al.
Publicado: (2018)