Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs
T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs.
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Nature Portfolio
2017
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oai:doaj.org-article:20f421d598244afda24290cb099f73c72021-12-02T14:40:47ZTranscribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs10.1038/s41467-017-01562-92041-1723https://doaj.org/article/20f421d598244afda24290cb099f73c72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01562-9https://doaj.org/toc/2041-1723T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs.Ivan VanniniPetra M. WiseKishore B. ChallagundlaMeropi PlousiouMirco RaffiniErika BandiniFrancesca FaniniGiorgia PaliagaMelissa CrawfordManuela FerracinCristina IvanLinda FabrisRamana V. DavuluriZhiyi GuoMaria Angelica CortezXinna ZhangLu ChenShuxing ZhangCecilia Fernandez-CymeringLeng HanSilvia CarloniSamanta SalviHui LingMariam MurtadhaPaolo NevianiBarbara J. GitlitzIte A. Laird-OffringaPatrick Nana-SinkamMassimo NegriniHan LiangDino AmadoriAmelia CimminoGeorge A. CalinMuller FabbriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017) |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Ivan Vannini Petra M. Wise Kishore B. Challagundla Meropi Plousiou Mirco Raffini Erika Bandini Francesca Fanini Giorgia Paliaga Melissa Crawford Manuela Ferracin Cristina Ivan Linda Fabris Ramana V. Davuluri Zhiyi Guo Maria Angelica Cortez Xinna Zhang Lu Chen Shuxing Zhang Cecilia Fernandez-Cymering Leng Han Silvia Carloni Samanta Salvi Hui Ling Mariam Murtadha Paolo Neviani Barbara J. Gitlitz Ite A. Laird-Offringa Patrick Nana-Sinkam Massimo Negrini Han Liang Dino Amadori Amelia Cimmino George A. Calin Muller Fabbri Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| description |
T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs. |
| format |
article |
| author |
Ivan Vannini Petra M. Wise Kishore B. Challagundla Meropi Plousiou Mirco Raffini Erika Bandini Francesca Fanini Giorgia Paliaga Melissa Crawford Manuela Ferracin Cristina Ivan Linda Fabris Ramana V. Davuluri Zhiyi Guo Maria Angelica Cortez Xinna Zhang Lu Chen Shuxing Zhang Cecilia Fernandez-Cymering Leng Han Silvia Carloni Samanta Salvi Hui Ling Mariam Murtadha Paolo Neviani Barbara J. Gitlitz Ite A. Laird-Offringa Patrick Nana-Sinkam Massimo Negrini Han Liang Dino Amadori Amelia Cimmino George A. Calin Muller Fabbri |
| author_facet |
Ivan Vannini Petra M. Wise Kishore B. Challagundla Meropi Plousiou Mirco Raffini Erika Bandini Francesca Fanini Giorgia Paliaga Melissa Crawford Manuela Ferracin Cristina Ivan Linda Fabris Ramana V. Davuluri Zhiyi Guo Maria Angelica Cortez Xinna Zhang Lu Chen Shuxing Zhang Cecilia Fernandez-Cymering Leng Han Silvia Carloni Samanta Salvi Hui Ling Mariam Murtadha Paolo Neviani Barbara J. Gitlitz Ite A. Laird-Offringa Patrick Nana-Sinkam Massimo Negrini Han Liang Dino Amadori Amelia Cimmino George A. Calin Muller Fabbri |
| author_sort |
Ivan Vannini |
| title |
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| title_short |
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| title_full |
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| title_fullStr |
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| title_full_unstemmed |
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs |
| title_sort |
transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor micrornas |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/20f421d598244afda24290cb099f73c7 |
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