Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility

K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment for disorders characterized by cognitive inflexibi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jia–Hua Hu, Cole Malloy, G. Travis Tabor, Jakob J. Gutzmann, Ying Liu, Daniel Abebe, Rose-Marie Karlsson, Stewart Durell, Heather A. Cameron, Dax A. Hoffman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20f42c6bb9064954b802b0b51ea31094
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20f42c6bb9064954b802b0b51ea31094
record_format	dspace
spelling	oai:doaj.org-article:20f42c6bb9064954b802b0b51ea310942021-12-02T14:41:01ZActivity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility10.1038/s41467-020-15390-x2041-1723https://doaj.org/article/20f42c6bb9064954b802b0b51ea310942020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15390-xhttps://doaj.org/toc/2041-1723K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment for disorders characterized by cognitive inflexibility.Jia–Hua HuCole MalloyG. Travis TaborJakob J. GutzmannYing LiuDaniel AbebeRose-Marie KarlssonStewart DurellHeather A. CameronDax A. HoffmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia–Hua Hu Cole Malloy G. Travis Tabor Jakob J. Gutzmann Ying Liu Daniel Abebe Rose-Marie Karlsson Stewart Durell Heather A. Cameron Dax A. Hoffman Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
description	K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment for disorders characterized by cognitive inflexibility.
format	article
author	Jia–Hua Hu Cole Malloy G. Travis Tabor Jakob J. Gutzmann Ying Liu Daniel Abebe Rose-Marie Karlsson Stewart Durell Heather A. Cameron Dax A. Hoffman
author_facet	Jia–Hua Hu Cole Malloy G. Travis Tabor Jakob J. Gutzmann Ying Liu Daniel Abebe Rose-Marie Karlsson Stewart Durell Heather A. Cameron Dax A. Hoffman
author_sort	Jia–Hua Hu
title	Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
title_short	Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
title_full	Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
title_fullStr	Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
title_full_unstemmed	Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
title_sort	activity-dependent isomerization of kv4.2 by pin1 regulates cognitive flexibility
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/20f42c6bb9064954b802b0b51ea31094
work_keys_str_mv	AT jiahuahu activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT colemalloy activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT gtravistabor activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT jakobjgutzmann activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT yingliu activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT danielabebe activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT rosemariekarlsson activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT stewartdurell activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT heatheracameron activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility AT daxahoffman activitydependentisomerizationofkv42bypin1regulatescognitiveflexibility
_version_	1718390040345706496

Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility

Ejemplares similares