ICER is requisite for Th17 differentiation

ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.

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Detalles Bibliográficos
Autores principales:	Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo, Florencia Rosetti, Tanya N. Mayadas, José C. Crispín, Sean J. Bradley, Tomohiro Koga, Michihito Kono, Maria P. Karampetsou, Vasileios C. Kyttaris, Klaus Tenbrock, George C. Tsokos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20f648b03a354e689528b9b09bfaa39f
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spelling	oai:doaj.org-article:20f648b03a354e689528b9b09bfaa39f2021-12-02T14:39:55ZICER is requisite for Th17 differentiation10.1038/ncomms129932041-1723https://doaj.org/article/20f648b03a354e689528b9b09bfaa39f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12993https://doaj.org/toc/2041-1723ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.Nobuya YoshidaDenis ComteMasayuki MizuiKotaro OtomoFlorencia RosettiTanya N. MayadasJosé C. CrispínSean J. BradleyTomohiro KogaMichihito KonoMaria P. KarampetsouVasileios C. KyttarisKlaus TenbrockGeorge C. TsokosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nobuya Yoshida Denis Comte Masayuki Mizui Kotaro Otomo Florencia Rosetti Tanya N. Mayadas José C. Crispín Sean J. Bradley Tomohiro Koga Michihito Kono Maria P. Karampetsou Vasileios C. Kyttaris Klaus Tenbrock George C. Tsokos ICER is requisite for Th17 differentiation
description	ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.
format	article
author	Nobuya Yoshida Denis Comte Masayuki Mizui Kotaro Otomo Florencia Rosetti Tanya N. Mayadas José C. Crispín Sean J. Bradley Tomohiro Koga Michihito Kono Maria P. Karampetsou Vasileios C. Kyttaris Klaus Tenbrock George C. Tsokos
author_facet	Nobuya Yoshida Denis Comte Masayuki Mizui Kotaro Otomo Florencia Rosetti Tanya N. Mayadas José C. Crispín Sean J. Bradley Tomohiro Koga Michihito Kono Maria P. Karampetsou Vasileios C. Kyttaris Klaus Tenbrock George C. Tsokos
author_sort	Nobuya Yoshida
title	ICER is requisite for Th17 differentiation
title_short	ICER is requisite for Th17 differentiation
title_full	ICER is requisite for Th17 differentiation
title_fullStr	ICER is requisite for Th17 differentiation
title_full_unstemmed	ICER is requisite for Th17 differentiation
title_sort	icer is requisite for th17 differentiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/20f648b03a354e689528b9b09bfaa39f
work_keys_str_mv	AT nobuyayoshida icerisrequisiteforth17differentiation AT deniscomte icerisrequisiteforth17differentiation AT masayukimizui icerisrequisiteforth17differentiation AT kotarootomo icerisrequisiteforth17differentiation AT florenciarosetti icerisrequisiteforth17differentiation AT tanyanmayadas icerisrequisiteforth17differentiation AT joseccrispin icerisrequisiteforth17differentiation AT seanjbradley icerisrequisiteforth17differentiation AT tomohirokoga icerisrequisiteforth17differentiation AT michihitokono icerisrequisiteforth17differentiation AT mariapkarampetsou icerisrequisiteforth17differentiation AT vasileiosckyttaris icerisrequisiteforth17differentiation AT klaustenbrock icerisrequisiteforth17differentiation AT georgectsokos icerisrequisiteforth17differentiation
_version_	1718390462132256768

ICER is requisite for Th17 differentiation

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