Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.

<h4>Background</h4>Chemerin has a potential role in perpetuating inflammation in autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated whether seru...

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Autores principales:	Fabiola Gonzalez-Ponce, Jorge I Gamez-Nava, Emilio E Perez-Guerrero, Ana M Saldaña-Cruz, Maria L Vazquez-Villegas, Juan M Ponce-Guarneros, Miguel Huerta, Xochitl Trujillo, Betsabe Contreras-Haro, Alberto D Rocha-Muñoz, Maria O Carrillo-Escalante, Esther N Sanchez-Rodriguez, Eli E Gomez-Ramirez, Cesar A Nava-Valdivia, Ernesto G Cardona-Muñoz, Laura Gonzalez-Lopez, Research Group for the Assessment of Prognosis Biomarkers in Autoimmune Disorders
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20f724e9c1af410cbf6a1606d7a3dde3
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spelling	oai:doaj.org-article:20f724e9c1af410cbf6a1606d7a3dde32021-12-02T20:08:21ZSerum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.1932-620310.1371/journal.pone.0255854https://doaj.org/article/20f724e9c1af410cbf6a1606d7a3dde32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255854https://doaj.org/toc/1932-6203<h4>Background</h4>Chemerin has a potential role in perpetuating inflammation in autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated whether serum chemerin is a biomarker of disease activity in RA patients.<h4>Methods</h4>Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) and fat mass. The severity of the disease activity was identified according to the DAS28-CRP index as follows: A) RA with a DAS28-CRP≤2.9 (remission/mild activity) and B) RA with a DAS28-CRP>2.9 (moderate/severe activity). Serum chemerin concentrations were measured by ELISA, and ≥103 ng/mL was considered a high level. Logistic regression analysis was applied to determine whether high chemerin levels were associated with disease activity in RA after adjusting for confounders. Multiple regression analysis was performed to identify variables associated with chemerin levels.<h4>Results</h4>Of 210 RA patients, 89 (42%) subjects had moderate/severe disease activity and had higher serum chemerin levels than patients with low disease activity or remission (86 ± 34 vs 73± 27; p = 0.003). Serum chemerin correlated with the number of swollen joints (r = 0.15; p = 0.03), DAS28-CRP (r = 0.22; p = 0.002), and C-reactive protein levels (r = 0.14; p = 0.04), but no correlation was observed with BMI and fat mass. In the adjusted logistic regression analysis, high chemerin levels (≥103 ng/mL) were associated with an increased risk of moderate/severe disease activity (OR: 2.76, 95% CI 1.35-5.62; p = 0.005). In the multiple regression analysis, after adjusting for potential confounders, serum chemerin levels were associated with higher DAS28-CRP (p = 0.002).<h4>Conclusions</h4>Higher chemerin levels increased the risk of moderate and severe disease activity in RA. These results support the role of chemerin as a marker of inflammation in RA. Follow-up studies will identify if maintaining low chemerin levels can be used as a therapeutic target.Fabiola Gonzalez-PonceJorge I Gamez-NavaEmilio E Perez-GuerreroAna M Saldaña-CruzMaria L Vazquez-VillegasJuan M Ponce-GuarnerosMiguel HuertaXochitl TrujilloBetsabe Contreras-HaroAlberto D Rocha-MuñozMaria O Carrillo-EscalanteEsther N Sanchez-RodriguezEli E Gomez-RamirezCesar A Nava-ValdiviaErnesto G Cardona-MuñozLaura Gonzalez-LopezResearch Group for the Assessment of Prognosis Biomarkers in Autoimmune DisordersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255854 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabiola Gonzalez-Ponce Jorge I Gamez-Nava Emilio E Perez-Guerrero Ana M Saldaña-Cruz Maria L Vazquez-Villegas Juan M Ponce-Guarneros Miguel Huerta Xochitl Trujillo Betsabe Contreras-Haro Alberto D Rocha-Muñoz Maria O Carrillo-Escalante Esther N Sanchez-Rodriguez Eli E Gomez-Ramirez Cesar A Nava-Valdivia Ernesto G Cardona-Muñoz Laura Gonzalez-Lopez Research Group for the Assessment of Prognosis Biomarkers in Autoimmune Disorders Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
description	<h4>Background</h4>Chemerin has a potential role in perpetuating inflammation in autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated whether serum chemerin is a biomarker of disease activity in RA patients.<h4>Methods</h4>Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) and fat mass. The severity of the disease activity was identified according to the DAS28-CRP index as follows: A) RA with a DAS28-CRP≤2.9 (remission/mild activity) and B) RA with a DAS28-CRP>2.9 (moderate/severe activity). Serum chemerin concentrations were measured by ELISA, and ≥103 ng/mL was considered a high level. Logistic regression analysis was applied to determine whether high chemerin levels were associated with disease activity in RA after adjusting for confounders. Multiple regression analysis was performed to identify variables associated with chemerin levels.<h4>Results</h4>Of 210 RA patients, 89 (42%) subjects had moderate/severe disease activity and had higher serum chemerin levels than patients with low disease activity or remission (86 ± 34 vs 73± 27; p = 0.003). Serum chemerin correlated with the number of swollen joints (r = 0.15; p = 0.03), DAS28-CRP (r = 0.22; p = 0.002), and C-reactive protein levels (r = 0.14; p = 0.04), but no correlation was observed with BMI and fat mass. In the adjusted logistic regression analysis, high chemerin levels (≥103 ng/mL) were associated with an increased risk of moderate/severe disease activity (OR: 2.76, 95% CI 1.35-5.62; p = 0.005). In the multiple regression analysis, after adjusting for potential confounders, serum chemerin levels were associated with higher DAS28-CRP (p = 0.002).<h4>Conclusions</h4>Higher chemerin levels increased the risk of moderate and severe disease activity in RA. These results support the role of chemerin as a marker of inflammation in RA. Follow-up studies will identify if maintaining low chemerin levels can be used as a therapeutic target.
format	article
author	Fabiola Gonzalez-Ponce Jorge I Gamez-Nava Emilio E Perez-Guerrero Ana M Saldaña-Cruz Maria L Vazquez-Villegas Juan M Ponce-Guarneros Miguel Huerta Xochitl Trujillo Betsabe Contreras-Haro Alberto D Rocha-Muñoz Maria O Carrillo-Escalante Esther N Sanchez-Rodriguez Eli E Gomez-Ramirez Cesar A Nava-Valdivia Ernesto G Cardona-Muñoz Laura Gonzalez-Lopez Research Group for the Assessment of Prognosis Biomarkers in Autoimmune Disorders
author_facet	Fabiola Gonzalez-Ponce Jorge I Gamez-Nava Emilio E Perez-Guerrero Ana M Saldaña-Cruz Maria L Vazquez-Villegas Juan M Ponce-Guarneros Miguel Huerta Xochitl Trujillo Betsabe Contreras-Haro Alberto D Rocha-Muñoz Maria O Carrillo-Escalante Esther N Sanchez-Rodriguez Eli E Gomez-Ramirez Cesar A Nava-Valdivia Ernesto G Cardona-Muñoz Laura Gonzalez-Lopez Research Group for the Assessment of Prognosis Biomarkers in Autoimmune Disorders
author_sort	Fabiola Gonzalez-Ponce
title	Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
title_short	Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
title_full	Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
title_fullStr	Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
title_full_unstemmed	Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.
title_sort	serum chemerin levels: a potential biomarker of joint inflammation in women with rheumatoid arthritis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/20f724e9c1af410cbf6a1606d7a3dde3
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Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.

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