The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma

Abstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested t...

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Autores principales:	Jixuan Liu, Hongyan Ban, Yafang Liu, Jinsong Ni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20f86582db934b19bd95885ae261cb53
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spelling	oai:doaj.org-article:20f86582db934b19bd95885ae261cb532021-12-02T18:02:14ZThe expression and significance of AKR1B10 in laryngeal squamous cell carcinoma10.1038/s41598-021-97648-y2045-2322https://doaj.org/article/20f86582db934b19bd95885ae261cb532021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97648-yhttps://doaj.org/toc/2045-2322Abstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported. However, we found that AKR1B10 is upregulated in laryngeal carcinoma, and its expression was negatively correlated with the degree of differentiation. In addition, AKR1B10 expression was positively correlated with tumor size; lymph node metastasis; alcohol use; and Ki-67, mutant p53, and matrix metalloproteinase 2 expression. AKR1B10 was overexpressed in Hep-2 laryngeal carcinoma cells. Oleanolic acid inhibited AKR1B10 activity and expression in Hep-2 cells and suppressed Hep-2 cell proliferation, migration, and invasion. Therefore, AKR1B10 may be related to the development of laryngeal carcinoma, suggesting its use as a prognostic indicator for laryngeal cancer.Jixuan LiuHongyan BanYafang LiuJinsong NiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
description	Abstract Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported. However, we found that AKR1B10 is upregulated in laryngeal carcinoma, and its expression was negatively correlated with the degree of differentiation. In addition, AKR1B10 expression was positively correlated with tumor size; lymph node metastasis; alcohol use; and Ki-67, mutant p53, and matrix metalloproteinase 2 expression. AKR1B10 was overexpressed in Hep-2 laryngeal carcinoma cells. Oleanolic acid inhibited AKR1B10 activity and expression in Hep-2 cells and suppressed Hep-2 cell proliferation, migration, and invasion. Therefore, AKR1B10 may be related to the development of laryngeal carcinoma, suggesting its use as a prognostic indicator for laryngeal cancer.
format	article
author	Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni
author_facet	Jixuan Liu Hongyan Ban Yafang Liu Jinsong Ni
author_sort	Jixuan Liu
title	The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
title_short	The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
title_full	The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
title_fullStr	The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
title_full_unstemmed	The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
title_sort	expression and significance of akr1b10 in laryngeal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/20f86582db934b19bd95885ae261cb53
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The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma

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