Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB disease, and upregulates the Dos regulon.

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Autores principales:	Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
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spelling	oai:doaj.org-article:20fabbdfe15b499283f6565afa5077d32021-12-02T14:40:30ZHydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis10.1038/s41467-019-14132-y2041-1723https://doaj.org/article/20fabbdfe15b499283f6565afa5077d32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14132-yhttps://doaj.org/toc/2041-1723The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB disease, and upregulates the Dos regulon.Vikram SainiKrishna C. ChintaVineel P. ReddyJoel N. GlasgowAsaf SteinDirk A. LamprechtMd. Aejazur RahmanJared S. MackenzieBarry E. TruebodyJohn H. AdamsonTafara T. R. KunotaShannon M. BaileyDouglas R. MoelleringJack R. LancasterAdrie J. C. SteynNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikram Saini Krishna C. Chinta Vineel P. Reddy Joel N. Glasgow Asaf Stein Dirk A. Lamprecht Md. Aejazur Rahman Jared S. Mackenzie Barry E. Truebody John H. Adamson Tafara T. R. Kunota Shannon M. Bailey Douglas R. Moellering Jack R. Lancaster Adrie J. C. Steyn Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
description	The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB disease, and upregulates the Dos regulon.
format	article
author	Vikram Saini Krishna C. Chinta Vineel P. Reddy Joel N. Glasgow Asaf Stein Dirk A. Lamprecht Md. Aejazur Rahman Jared S. Mackenzie Barry E. Truebody John H. Adamson Tafara T. R. Kunota Shannon M. Bailey Douglas R. Moellering Jack R. Lancaster Adrie J. C. Steyn
author_facet	Vikram Saini Krishna C. Chinta Vineel P. Reddy Joel N. Glasgow Asaf Stein Dirk A. Lamprecht Md. Aejazur Rahman Jared S. Mackenzie Barry E. Truebody John H. Adamson Tafara T. R. Kunota Shannon M. Bailey Douglas R. Moellering Jack R. Lancaster Adrie J. C. Steyn
author_sort	Vikram Saini
title	Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
title_short	Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
title_full	Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
title_fullStr	Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
title_full_unstemmed	Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
title_sort	hydrogen sulfide stimulates mycobacterium tuberculosis respiration, growth and pathogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
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Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

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