Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for autophagosomal degradation.

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Autores principales:	Nari Kim, Min-Jung Kim, Pil Soo Sung, Yong Chul Bae, Eui-Cheol Shin, Joo-Yeon Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20fbe11a80a84375aecf98c4c91b4005
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spelling	oai:doaj.org-article:20fbe11a80a84375aecf98c4c91b40052021-12-02T14:39:11ZInterferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A10.1038/ncomms106312041-1723https://doaj.org/article/20fbe11a80a84375aecf98c4c91b40052016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10631https://doaj.org/toc/2041-1723Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for autophagosomal degradation.Nari KimMin-Jung KimPil Soo SungYong Chul BaeEui-Cheol ShinJoo-Yeon YooNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nari Kim Min-Jung Kim Pil Soo Sung Yong Chul Bae Eui-Cheol Shin Joo-Yeon Yoo Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
description	Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for autophagosomal degradation.
format	article
author	Nari Kim Min-Jung Kim Pil Soo Sung Yong Chul Bae Eui-Cheol Shin Joo-Yeon Yoo
author_facet	Nari Kim Min-Jung Kim Pil Soo Sung Yong Chul Bae Eui-Cheol Shin Joo-Yeon Yoo
author_sort	Nari Kim
title	Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
title_short	Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
title_full	Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
title_fullStr	Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
title_full_unstemmed	Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
title_sort	interferon-inducible protein scotin interferes with hcv replication through the autolysosomal degradation of ns5a
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/20fbe11a80a84375aecf98c4c91b4005
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Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

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