Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for autophagosomal degradation.

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Autores principales: Nari Kim, Min-Jung Kim, Pil Soo Sung, Yong Chul Bae, Eui-Cheol Shin, Joo-Yeon Yoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/20fbe11a80a84375aecf98c4c91b4005
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