H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression

The effects of epigenetic regulators on different tumor cell populations can affect their potential as anticancer targets. In this study, the authors demonstrate that the histone methyltransferase G9a is a suppressor of lung tumor-propagating cells and tumor progression, acting through chromatin mod...

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Autores principales:	S. P. Rowbotham, F. Li, A. F. M. Dost, S. M. Louie, B. P. Marsh, P. Pessina, C. R. Anbarasu, C. F. Brainson, S. J. Tuminello, A. Lieberman, S. Ryeom, T. M. Schlaeger, B. J. Aronow, H. Watanabe, K. K. Wong, C. F. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20fdd8a1be4f48d08d01599ffa5304ca
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spelling	oai:doaj.org-article:20fdd8a1be4f48d08d01599ffa5304ca2021-12-02T15:34:01ZH3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression10.1038/s41467-018-07077-12041-1723https://doaj.org/article/20fdd8a1be4f48d08d01599ffa5304ca2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07077-1https://doaj.org/toc/2041-1723The effects of epigenetic regulators on different tumor cell populations can affect their potential as anticancer targets. In this study, the authors demonstrate that the histone methyltransferase G9a is a suppressor of lung tumor-propagating cells and tumor progression, acting through chromatin modification with MMP10 as one of its targets for metastasis regulation.S. P. RowbothamF. LiA. F. M. DostS. M. LouieB. P. MarshP. PessinaC. R. AnbarasuC. F. BrainsonS. J. TuminelloA. LiebermanS. RyeomT. M. SchlaegerB. J. AronowH. WatanabeK. K. WongC. F. KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. P. Rowbotham F. Li A. F. M. Dost S. M. Louie B. P. Marsh P. Pessina C. R. Anbarasu C. F. Brainson S. J. Tuminello A. Lieberman S. Ryeom T. M. Schlaeger B. J. Aronow H. Watanabe K. K. Wong C. F. Kim H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
description	The effects of epigenetic regulators on different tumor cell populations can affect their potential as anticancer targets. In this study, the authors demonstrate that the histone methyltransferase G9a is a suppressor of lung tumor-propagating cells and tumor progression, acting through chromatin modification with MMP10 as one of its targets for metastasis regulation.
format	article
author	S. P. Rowbotham F. Li A. F. M. Dost S. M. Louie B. P. Marsh P. Pessina C. R. Anbarasu C. F. Brainson S. J. Tuminello A. Lieberman S. Ryeom T. M. Schlaeger B. J. Aronow H. Watanabe K. K. Wong C. F. Kim
author_facet	S. P. Rowbotham F. Li A. F. M. Dost S. M. Louie B. P. Marsh P. Pessina C. R. Anbarasu C. F. Brainson S. J. Tuminello A. Lieberman S. Ryeom T. M. Schlaeger B. J. Aronow H. Watanabe K. K. Wong C. F. Kim
author_sort	S. P. Rowbotham
title	H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
title_short	H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
title_full	H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
title_fullStr	H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
title_full_unstemmed	H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
title_sort	h3k9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/20fdd8a1be4f48d08d01599ffa5304ca
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H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression

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