Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis

Currently, HIV infection is characterized by emergence of its severe and comorbid forms. Mid-1990 HIV epidemics was expanded due to injection drug users who brought viral hepatitis C to the cohort. Along with developing immunosuppression, opportunistic and AIDS-defining diseases, including tuberculo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. V. Azovtseva, A. M. Panteleev, А. V. Кarpov, G. S. Arkhipov, V. R. Veber, N. A. Belyakov, E. I. Arkhipova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	tuberculosis coinfection (hiv infection viral hepatitis) cd4 lymphocytes Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/210094a736a74e119c384f951a9b99e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:210094a736a74e119c384f951a9b99e6
record_format	dspace
spelling	oai:doaj.org-article:210094a736a74e119c384f951a9b99e62021-11-22T07:09:53ZAnalysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis2220-76192313-739810.15789/2220-7619-2019-5-6-787-799https://doaj.org/article/210094a736a74e119c384f951a9b99e62020-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/815https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Currently, HIV infection is characterized by emergence of its severe and comorbid forms. Mid-1990 HIV epidemics was expanded due to injection drug users who brought viral hepatitis C to the cohort. Along with developing immunosuppression, opportunistic and AIDS-defining diseases, including tuberculosis emerged. Various combinations of coinfections (HIV infection+tuberculosis±viral hepatitis) affect clinical manifestations and clinical score, reduce the therapeutic efficacy and worsen disease prognosis.Objective: to study an impact medical and social factors on course of TB-co-infection associated with immunosuppression related to HIV infection and viral hepatitis.Materials and methods. Comorbid cases (HIV infection, tuberculosis and chronic hepatitis) dominated by verified TB-infection (n = 137) were analyzed.Results. It was shown that socially maladapted young people with previous experience of intravenous drug and alcohol abuse dominated among subjects with co-infections, half of which were held in penal institutions. More-over, the mean CD4 lymphocyte level in generalized tuberculosis was significantly lower than in patients with significantly reaching 164±21.5 cells. In addition, lung-specific lesions were observed in 73.4% of patients with generalized tuberculosis that developed by initial targeting of the lymphoid system followed by affecting other organs, mainly the central nervous system, urinary system and abdominal organs. Introduction of antiretroviral drugs to anti-TB therapy reduced mortality rate by 8 times. Viral hepatitis was the most common concomitant disease found in co-infected patients, with dominating viral hepatitis C both as a mono-infection (86.8%) as well as in combination with viral hepatitis B (9.43%). In addition, co-morbid viral hepatitis resulted in progression of TB infection affected due to intra-thoracic lymph nodes being involved in tuberculosis process as well as development of opportunistic diseases due to a markedly decreased CD4 cell count. Analysis of potentially aggravating risk factors for developing hepatotoxicity (viral hepatitis, combined treatment with anti-TB and anti-retroviral drugs) did not reveal their any additional negative impact on hepatic functions. Thus, use of a combination therapy with anti-TB and anti-retroviral drugs in co-infected patients was shown to be safe and not accompanied by a high rate of hepatotoxic reactions.O. V. AzovtsevaA. M. PanteleevА. V. КarpovG. S. ArkhipovV. R. VeberN. A. BelyakovE. I. ArkhipovaSankt-Peterburg : NIIÈM imeni Pasteraarticletuberculosiscoinfection (hiv infectionviral hepatitis)cd4 lymphocytesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 5-6, Pp 787-799 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis coinfection (hiv infection viral hepatitis) cd4 lymphocytes Infectious and parasitic diseases RC109-216
spellingShingle	tuberculosis coinfection (hiv infection viral hepatitis) cd4 lymphocytes Infectious and parasitic diseases RC109-216 O. V. Azovtseva A. M. Panteleev А. V. Кarpov G. S. Arkhipov V. R. Veber N. A. Belyakov E. I. Arkhipova Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
description	Currently, HIV infection is characterized by emergence of its severe and comorbid forms. Mid-1990 HIV epidemics was expanded due to injection drug users who brought viral hepatitis C to the cohort. Along with developing immunosuppression, opportunistic and AIDS-defining diseases, including tuberculosis emerged. Various combinations of coinfections (HIV infection+tuberculosis±viral hepatitis) affect clinical manifestations and clinical score, reduce the therapeutic efficacy and worsen disease prognosis.Objective: to study an impact medical and social factors on course of TB-co-infection associated with immunosuppression related to HIV infection and viral hepatitis.Materials and methods. Comorbid cases (HIV infection, tuberculosis and chronic hepatitis) dominated by verified TB-infection (n = 137) were analyzed.Results. It was shown that socially maladapted young people with previous experience of intravenous drug and alcohol abuse dominated among subjects with co-infections, half of which were held in penal institutions. More-over, the mean CD4 lymphocyte level in generalized tuberculosis was significantly lower than in patients with significantly reaching 164±21.5 cells. In addition, lung-specific lesions were observed in 73.4% of patients with generalized tuberculosis that developed by initial targeting of the lymphoid system followed by affecting other organs, mainly the central nervous system, urinary system and abdominal organs. Introduction of antiretroviral drugs to anti-TB therapy reduced mortality rate by 8 times. Viral hepatitis was the most common concomitant disease found in co-infected patients, with dominating viral hepatitis C both as a mono-infection (86.8%) as well as in combination with viral hepatitis B (9.43%). In addition, co-morbid viral hepatitis resulted in progression of TB infection affected due to intra-thoracic lymph nodes being involved in tuberculosis process as well as development of opportunistic diseases due to a markedly decreased CD4 cell count. Analysis of potentially aggravating risk factors for developing hepatotoxicity (viral hepatitis, combined treatment with anti-TB and anti-retroviral drugs) did not reveal their any additional negative impact on hepatic functions. Thus, use of a combination therapy with anti-TB and anti-retroviral drugs in co-infected patients was shown to be safe and not accompanied by a high rate of hepatotoxic reactions.
format	article
author	O. V. Azovtseva A. M. Panteleev А. V. Кarpov G. S. Arkhipov V. R. Veber N. A. Belyakov E. I. Arkhipova
author_facet	O. V. Azovtseva A. M. Panteleev А. V. Кarpov G. S. Arkhipov V. R. Veber N. A. Belyakov E. I. Arkhipova
author_sort	O. V. Azovtseva
title	Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
title_short	Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
title_full	Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
title_fullStr	Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
title_full_unstemmed	Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis
title_sort	analysis of medical and social factors affecting the formation and course of co-infection hiv, tuberculosis and viral hepatitis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/210094a736a74e119c384f951a9b99e6
work_keys_str_mv	AT ovazovtseva analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT ampanteleev analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT avkarpov analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT gsarkhipov analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT vrveber analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT nabelyakov analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis AT eiarkhipova analysisofmedicalandsocialfactorsaffectingtheformationandcourseofcoinfectionhivtuberculosisandviralhepatitis
_version_	1718417903977496576

Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis

Ejemplares similares