A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain

Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus lignocaine) (EMLA) for reducing the severity of pain....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	AH. Rudresha, Bipinesh Sansar, D. Lokanath, Linu Abraham Jacob, M.C. Suresh Babu, Lokesh K. N., Smitha C. Saldanha, Shina Goyal, L. K. Rajeev
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	aspiration bone marrow emla pain tramadol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/21011420672a4b2f9d2f6af910594690
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:21011420672a4b2f9d2f6af910594690
record_format	dspace
spelling	oai:doaj.org-article:21011420672a4b2f9d2f6af9105946902021-11-12T00:02:41ZA Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain2278-330X2278-430610.1055/s-0041-1731904https://doaj.org/article/21011420672a4b2f9d2f6af9105946902021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731904https://doaj.org/toc/2278-330Xhttps://doaj.org/toc/2278-4306Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus lignocaine) (EMLA) for reducing the severity of pain. Materials and Methods In this pilot study, we compared the addition of either tramadol 50 mg per oral (T) or EMLA local application (E) or no intervention (L) in addition to the usual procedure of local infiltration with lignocaine 2% before bone marrow aspiration and biopsy (BMAB) in adults suspected/confirmed with malignancy. Both, tramadol and EMLA were administered 1 hour prior to the procedure. Primary end point was reduction in pain intensity with these interventions compared with local infiltration alone. Pain was assessed using numerical FACES pain scale, a visual analogue scale. Secondary end points were to see the effect on pre procedure apprehension and to find out the other factors associated with increased pain related to the procedure. Statistical Analysis and Results A total of 300 patients were included in the study, 100 each in tramadol (T), EMLA (E), and only lignocaine local infiltration (L) arms, respectively. The mean pain intensity on the visual scale was significantly lower in the tramadol arm (T, E, L—3.4, 4.4, 4.7, respectively) (p < 0.0005). There was a significant reduction in percentage of patients who experienced moderate/severe pain (four or more) in the tramadol arm (T, E, L—45, 77, 82%, respectively) (p < 0.0005). Duration of procedure >10 minutes, body mass index >30, ECOG (Eastern Oncology Group) performance status ≥3, and age >50 years were positively correlated with more pain. Leukemia patients experienced significantly more pain compared with patients with lymphoma and other solid malignancies. Tramadol was well tolerated. No significant effect on pre-procedure apprehension was noted in any of the arms. Conclusion Tramadol appears to have a preventive effect on bone marrow aspiration/biopsy-associated pain and appears to be well tolerated, whereas EMLA was not associated with such an effect. Larger studies may be done to ascertain the same.AH. RudreshaBipinesh SansarD. LokanathLinu Abraham JacobM.C. Suresh BabuLokesh K. N.Smitha C. SaldanhaShina GoyalL. K. RajeevThieme Medical and Scientific Publishers Pvt. Ltd.articleaspirationbone marrowemlapaintramadolNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENSouth Asian Journal of Cancer (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspiration bone marrow emla pain tramadol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	aspiration bone marrow emla pain tramadol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 AH. Rudresha Bipinesh Sansar D. Lokanath Linu Abraham Jacob M.C. Suresh Babu Lokesh K. N. Smitha C. Saldanha Shina Goyal L. K. Rajeev A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
description	Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus lignocaine) (EMLA) for reducing the severity of pain. Materials and Methods In this pilot study, we compared the addition of either tramadol 50 mg per oral (T) or EMLA local application (E) or no intervention (L) in addition to the usual procedure of local infiltration with lignocaine 2% before bone marrow aspiration and biopsy (BMAB) in adults suspected/confirmed with malignancy. Both, tramadol and EMLA were administered 1 hour prior to the procedure. Primary end point was reduction in pain intensity with these interventions compared with local infiltration alone. Pain was assessed using numerical FACES pain scale, a visual analogue scale. Secondary end points were to see the effect on pre procedure apprehension and to find out the other factors associated with increased pain related to the procedure. Statistical Analysis and Results A total of 300 patients were included in the study, 100 each in tramadol (T), EMLA (E), and only lignocaine local infiltration (L) arms, respectively. The mean pain intensity on the visual scale was significantly lower in the tramadol arm (T, E, L—3.4, 4.4, 4.7, respectively) (p < 0.0005). There was a significant reduction in percentage of patients who experienced moderate/severe pain (four or more) in the tramadol arm (T, E, L—45, 77, 82%, respectively) (p < 0.0005). Duration of procedure >10 minutes, body mass index >30, ECOG (Eastern Oncology Group) performance status ≥3, and age >50 years were positively correlated with more pain. Leukemia patients experienced significantly more pain compared with patients with lymphoma and other solid malignancies. Tramadol was well tolerated. No significant effect on pre-procedure apprehension was noted in any of the arms. Conclusion Tramadol appears to have a preventive effect on bone marrow aspiration/biopsy-associated pain and appears to be well tolerated, whereas EMLA was not associated with such an effect. Larger studies may be done to ascertain the same.
format	article
author	AH. Rudresha Bipinesh Sansar D. Lokanath Linu Abraham Jacob M.C. Suresh Babu Lokesh K. N. Smitha C. Saldanha Shina Goyal L. K. Rajeev
author_facet	AH. Rudresha Bipinesh Sansar D. Lokanath Linu Abraham Jacob M.C. Suresh Babu Lokesh K. N. Smitha C. Saldanha Shina Goyal L. K. Rajeev
author_sort	AH. Rudresha
title	A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
title_short	A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
title_full	A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
title_fullStr	A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
title_full_unstemmed	A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
title_sort	pilot study on the addition of tramadol or eutectic mixture of local anesthetics (prilocaine plus lignocaine) to local lignocaine infiltration for prevention of bone marrow aspiration/biopsy associated pain
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/21011420672a4b2f9d2f6af910594690
work_keys_str_mv	AT ahrudresha apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT bipineshsansar apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT dlokanath apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT linuabrahamjacob apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT mcsureshbabu apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT lokeshkn apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT smithacsaldanha apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT shinagoyal apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT lkrajeev apilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT ahrudresha pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT bipineshsansar pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT dlokanath pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT linuabrahamjacob pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT mcsureshbabu pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT lokeshkn pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT smithacsaldanha pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT shinagoyal pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain AT lkrajeev pilotstudyontheadditionoftramadoloreutecticmixtureoflocalanestheticsprilocainepluslignocainetolocallignocaineinfiltrationforpreventionofbonemarrowaspirationbiopsyassociatedpain
_version_	1718431335632076800

A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain

Ejemplares similares