Orthobunyavirus spike architecture and recognition by neutralizing antibodies

Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jan Hellert, Andrea Aebischer, Kerstin Wernike, Ahmed Haouz, Emiliana Brocchi, Sven Reiche, Pablo Guardado-Calvo, Martin Beer, Félix A. Rey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2104c270a93148418cef93bdd6763c5f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2104c270a93148418cef93bdd6763c5f
record_format	dspace
spelling	oai:doaj.org-article:2104c270a93148418cef93bdd6763c5f2021-12-02T17:01:59ZOrthobunyavirus spike architecture and recognition by neutralizing antibodies10.1038/s41467-019-08832-82041-1723https://doaj.org/article/2104c270a93148418cef93bdd6763c5f2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08832-8https://doaj.org/toc/2041-1723Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.Jan HellertAndrea AebischerKerstin WernikeAhmed HaouzEmiliana BrocchiSven ReichePablo Guardado-CalvoMartin BeerFélix A. ReyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jan Hellert Andrea Aebischer Kerstin Wernike Ahmed Haouz Emiliana Brocchi Sven Reiche Pablo Guardado-Calvo Martin Beer Félix A. Rey Orthobunyavirus spike architecture and recognition by neutralizing antibodies
description	Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.
format	article
author	Jan Hellert Andrea Aebischer Kerstin Wernike Ahmed Haouz Emiliana Brocchi Sven Reiche Pablo Guardado-Calvo Martin Beer Félix A. Rey
author_facet	Jan Hellert Andrea Aebischer Kerstin Wernike Ahmed Haouz Emiliana Brocchi Sven Reiche Pablo Guardado-Calvo Martin Beer Félix A. Rey
author_sort	Jan Hellert
title	Orthobunyavirus spike architecture and recognition by neutralizing antibodies
title_short	Orthobunyavirus spike architecture and recognition by neutralizing antibodies
title_full	Orthobunyavirus spike architecture and recognition by neutralizing antibodies
title_fullStr	Orthobunyavirus spike architecture and recognition by neutralizing antibodies
title_full_unstemmed	Orthobunyavirus spike architecture and recognition by neutralizing antibodies
title_sort	orthobunyavirus spike architecture and recognition by neutralizing antibodies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2104c270a93148418cef93bdd6763c5f
work_keys_str_mv	AT janhellert orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT andreaaebischer orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT kerstinwernike orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT ahmedhaouz orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT emilianabrocchi orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT svenreiche orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT pabloguardadocalvo orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT martinbeer orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies AT felixarey orthobunyavirusspikearchitectureandrecognitionbyneutralizingantibodies
_version_	1718381955236495360

Orthobunyavirus spike architecture and recognition by neutralizing antibodies

Ejemplares similares