Residue 6.43 defines receptor function in class F GPCRs

The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational changes, while SMO manifests a preference for a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ainoleena Turku, Hannes Schihada, Pawel Kozielewicz, Carl-Fredrik Bowin, Gunnar Schulte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/210a27d0ce7040bd89c4edb6636fa89d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:210a27d0ce7040bd89c4edb6636fa89d
record_format	dspace
spelling	oai:doaj.org-article:210a27d0ce7040bd89c4edb6636fa89d2021-12-02T17:12:16ZResidue 6.43 defines receptor function in class F GPCRs10.1038/s41467-021-24004-z2041-1723https://doaj.org/article/210a27d0ce7040bd89c4edb6636fa89d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24004-zhttps://doaj.org/toc/2041-1723The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational changes, while SMO manifests a preference for a straight TM6, the TM6 of FZDs is kinked upon activation.Ainoleena TurkuHannes SchihadaPawel KozielewiczCarl-Fredrik BowinGunnar SchulteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ainoleena Turku Hannes Schihada Pawel Kozielewicz Carl-Fredrik Bowin Gunnar Schulte Residue 6.43 defines receptor function in class F GPCRs
description	The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational changes, while SMO manifests a preference for a straight TM6, the TM6 of FZDs is kinked upon activation.
format	article
author	Ainoleena Turku Hannes Schihada Pawel Kozielewicz Carl-Fredrik Bowin Gunnar Schulte
author_facet	Ainoleena Turku Hannes Schihada Pawel Kozielewicz Carl-Fredrik Bowin Gunnar Schulte
author_sort	Ainoleena Turku
title	Residue 6.43 defines receptor function in class F GPCRs
title_short	Residue 6.43 defines receptor function in class F GPCRs
title_full	Residue 6.43 defines receptor function in class F GPCRs
title_fullStr	Residue 6.43 defines receptor function in class F GPCRs
title_full_unstemmed	Residue 6.43 defines receptor function in class F GPCRs
title_sort	residue 6.43 defines receptor function in class f gpcrs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/210a27d0ce7040bd89c4edb6636fa89d
work_keys_str_mv	AT ainoleenaturku residue643definesreceptorfunctioninclassfgpcrs AT hannesschihada residue643definesreceptorfunctioninclassfgpcrs AT pawelkozielewicz residue643definesreceptorfunctioninclassfgpcrs AT carlfredrikbowin residue643definesreceptorfunctioninclassfgpcrs AT gunnarschulte residue643definesreceptorfunctioninclassfgpcrs
_version_	1718381423306473472

Residue 6.43 defines receptor function in class F GPCRs

Ejemplares similares