Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

Abstract SARS-CoV-2 infection ranges from asymptomatic to severe with lingering symptomatology in some. This prompted investigation of whether or not asymptomatic disease results in measurable immune activation post-infection. Immune activation following asymptomatic SARS-CoV-2 infection was charact...

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Autores principales:	Hye Kyung Lee, Ludwig Knabl, Lisa Pipperger, Andre Volland, Priscilla A. Furth, Keunsoo Kang, Harold E. Smith, Romuald Bellmann, Christina Bernhard, Norbert Kaiser, Hannes Gänzer, Mathias Ströhle, Andreas Walser, Dorothee von Laer, Lothar Hennighausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/210d5784963444e28175c13a1924d367
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spelling	oai:doaj.org-article:210d5784963444e28175c13a1924d3672021-12-02T10:54:30ZImmune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community10.1038/s41598-021-83110-62045-2322https://doaj.org/article/210d5784963444e28175c13a1924d3672021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83110-6https://doaj.org/toc/2045-2322Abstract SARS-CoV-2 infection ranges from asymptomatic to severe with lingering symptomatology in some. This prompted investigation of whether or not asymptomatic disease results in measurable immune activation post-infection. Immune activation following asymptomatic SARS-CoV-2 infection was characterized through a comparative investigation of the immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals from the same community 4–6 weeks following a superspreading event. Few of the 95 individuals had underlying health issues. One seropositive individual reported Cystic Fibrosis and one individual reported Incontinentia pigmenti. No evidence of immune activation was found in asymptomatic seropositive individuals with the exception of the Cystic Fibrosis patient. There were no statistically significant differences in immune transcriptomes between asymptomatic seropositive and highly exposed seronegative individuals. Four positive controls, mildly symptomatic seropositive individuals whose blood was examined 3 weeks following infection, showed immune activation. Negative controls were four seronegative individuals from neighboring communities without COVID-19. All individuals remained in their usual state of health through a five-month follow-up after sample collection. In summary, whole blood transcriptomes identified individual immune profiles within a community population and showed that asymptomatic infection within a super-spreading event was not associated with enduring immunological activation.Hye Kyung LeeLudwig KnablLisa PippergerAndre VollandPriscilla A. FurthKeunsoo KangHarold E. SmithLudwig KnablRomuald BellmannChristina BernhardNorbert KaiserHannes GänzerMathias StröhleAndreas WalserDorothee von LaerLothar HennighausenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Kyung Lee Ludwig Knabl Lisa Pipperger Andre Volland Priscilla A. Furth Keunsoo Kang Harold E. Smith Ludwig Knabl Romuald Bellmann Christina Bernhard Norbert Kaiser Hannes Gänzer Mathias Ströhle Andreas Walser Dorothee von Laer Lothar Hennighausen Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
description	Abstract SARS-CoV-2 infection ranges from asymptomatic to severe with lingering symptomatology in some. This prompted investigation of whether or not asymptomatic disease results in measurable immune activation post-infection. Immune activation following asymptomatic SARS-CoV-2 infection was characterized through a comparative investigation of the immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals from the same community 4–6 weeks following a superspreading event. Few of the 95 individuals had underlying health issues. One seropositive individual reported Cystic Fibrosis and one individual reported Incontinentia pigmenti. No evidence of immune activation was found in asymptomatic seropositive individuals with the exception of the Cystic Fibrosis patient. There were no statistically significant differences in immune transcriptomes between asymptomatic seropositive and highly exposed seronegative individuals. Four positive controls, mildly symptomatic seropositive individuals whose blood was examined 3 weeks following infection, showed immune activation. Negative controls were four seronegative individuals from neighboring communities without COVID-19. All individuals remained in their usual state of health through a five-month follow-up after sample collection. In summary, whole blood transcriptomes identified individual immune profiles within a community population and showed that asymptomatic infection within a super-spreading event was not associated with enduring immunological activation.
format	article
author	Hye Kyung Lee Ludwig Knabl Lisa Pipperger Andre Volland Priscilla A. Furth Keunsoo Kang Harold E. Smith Ludwig Knabl Romuald Bellmann Christina Bernhard Norbert Kaiser Hannes Gänzer Mathias Ströhle Andreas Walser Dorothee von Laer Lothar Hennighausen
author_facet	Hye Kyung Lee Ludwig Knabl Lisa Pipperger Andre Volland Priscilla A. Furth Keunsoo Kang Harold E. Smith Ludwig Knabl Romuald Bellmann Christina Bernhard Norbert Kaiser Hannes Gänzer Mathias Ströhle Andreas Walser Dorothee von Laer Lothar Hennighausen
author_sort	Hye Kyung Lee
title	Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_short	Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_full	Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_fullStr	Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_full_unstemmed	Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_sort	immune transcriptomes of highly exposed sars-cov-2 asymptomatic seropositive versus seronegative individuals from the ischgl community
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/210d5784963444e28175c13a1924d367
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Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

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