Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults

Abstract Background Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of adva...

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Autores principales:	Mia Klinkvort Kempel, Trine Nøhr Winding, Vibeke Lynggaard, Steven Brantlov, Johan Hviid Andersen, Morten Böttcher
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	body mass index cardiovascular risk inflammation obesity risk management Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/2110e51270cc43e9963634d87e146bb9
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spelling	oai:doaj.org-article:2110e51270cc43e9963634d87e146bb92021-12-01T08:57:17ZTraditional and novel cardiometabolic risk markers across strata of body mass index in young adults2055-223810.1002/osp4.528https://doaj.org/article/2110e51270cc43e9963634d87e146bb92021-12-01T00:00:00Zhttps://doi.org/10.1002/osp4.528https://doaj.org/toc/2055-2238Abstract Background Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of advanced cardiac imaging for risk assessment in young adults is, therefore, necessary. Objective This study aims to explore traditional and novel cardiometabolic risk markers across strata of BMI in young adults. Methods Participants (N = 264, 50% women, age 28–30 years) were invited from an ongoing cohort study, based on BMI and sex. BMI‐strata were: BMI <25, 25–30, >30 kg/m2, representing normal weight (NW), overweight (OW), and obesity (OB). Participants underwent cardiac computed tomography to detect coronary artery calcification, measures of body composition, blood pressure measurements, and a comprehensive panel of circulating cardiometabolic risk markers. Results No significant coronary artery calcifications were detected in this study. Minor differences in median levels of traditional risk markers were detected across BMI‐strata, for example, total cholesterol (men‐ NW: 4.7 (4.3–5.1) and OB: 4.8 (4.2–5.6) mmol/L, p = 0.58; women‐ NW: 4.3 (3.9–4.8) and OB: 4.7 (4.2–5.3) mmol/L, p = 0.016), whereas substantial differences were seen in markers of inflammation and glucose metabolism, for example, high sensitive CRP (men‐ NW: 0.6 (0.3–1.1) and OB: 2.8 (1.5–4.0) mg/L, p < 0.001; women‐ NW: 0.7 (0.3–1.7) and OB: 4.0 (2.2–7.8) mg/L, p < 0.001) and insulin (men‐ NW: 47.0 (35.0–59.0) and OB: 113.5 (72.0–151.0) pmol/L, p < 0.001; women‐ NW: 44.0 (35.0–60.0) and OB: 84.5 (60.0–126.0) pmol/L, p < 0.001). Conclusion In young adults, obesity is associated with an early onset insulin resistance and inflammatory response prior to development of coronary artery calcification and deterioration of lipid profiles.Mia Klinkvort KempelTrine Nøhr WindingVibeke LynggaardSteven BrantlovJohan Hviid AndersenMorten BöttcherWileyarticlebody mass indexcardiovascular riskinflammationobesityrisk managementInternal medicineRC31-1245ENObesity Science & Practice, Vol 7, Iss 6, Pp 727-737 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body mass index cardiovascular risk inflammation obesity risk management Internal medicine RC31-1245
spellingShingle	body mass index cardiovascular risk inflammation obesity risk management Internal medicine RC31-1245 Mia Klinkvort Kempel Trine Nøhr Winding Vibeke Lynggaard Steven Brantlov Johan Hviid Andersen Morten Böttcher Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
description	Abstract Background Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of advanced cardiac imaging for risk assessment in young adults is, therefore, necessary. Objective This study aims to explore traditional and novel cardiometabolic risk markers across strata of BMI in young adults. Methods Participants (N = 264, 50% women, age 28–30 years) were invited from an ongoing cohort study, based on BMI and sex. BMI‐strata were: BMI <25, 25–30, >30 kg/m2, representing normal weight (NW), overweight (OW), and obesity (OB). Participants underwent cardiac computed tomography to detect coronary artery calcification, measures of body composition, blood pressure measurements, and a comprehensive panel of circulating cardiometabolic risk markers. Results No significant coronary artery calcifications were detected in this study. Minor differences in median levels of traditional risk markers were detected across BMI‐strata, for example, total cholesterol (men‐ NW: 4.7 (4.3–5.1) and OB: 4.8 (4.2–5.6) mmol/L, p = 0.58; women‐ NW: 4.3 (3.9–4.8) and OB: 4.7 (4.2–5.3) mmol/L, p = 0.016), whereas substantial differences were seen in markers of inflammation and glucose metabolism, for example, high sensitive CRP (men‐ NW: 0.6 (0.3–1.1) and OB: 2.8 (1.5–4.0) mg/L, p < 0.001; women‐ NW: 0.7 (0.3–1.7) and OB: 4.0 (2.2–7.8) mg/L, p < 0.001) and insulin (men‐ NW: 47.0 (35.0–59.0) and OB: 113.5 (72.0–151.0) pmol/L, p < 0.001; women‐ NW: 44.0 (35.0–60.0) and OB: 84.5 (60.0–126.0) pmol/L, p < 0.001). Conclusion In young adults, obesity is associated with an early onset insulin resistance and inflammatory response prior to development of coronary artery calcification and deterioration of lipid profiles.
format	article
author	Mia Klinkvort Kempel Trine Nøhr Winding Vibeke Lynggaard Steven Brantlov Johan Hviid Andersen Morten Böttcher
author_facet	Mia Klinkvort Kempel Trine Nøhr Winding Vibeke Lynggaard Steven Brantlov Johan Hviid Andersen Morten Böttcher
author_sort	Mia Klinkvort Kempel
title	Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_short	Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_full	Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_fullStr	Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_full_unstemmed	Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_sort	traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2110e51270cc43e9963634d87e146bb9
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Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults

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