Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better...

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Autores principales:	Hui Zhang, Edward S. Hui, Peng Cao, Henry K. F. Mak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amyloid-β deposition Alzheimer’s disease coupling between functional and structural networks <sup>18</sup>F-flutemetamol PET-CT resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/211281462a6045ec9b58b9f5842d18d0
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spelling	oai:doaj.org-article:211281462a6045ec9b58b9f5842d18d02021-11-25T16:59:16ZRelationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease10.3390/brainsci111115352076-3425https://doaj.org/article/211281462a6045ec9b58b9f5842d18d02021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1535https://doaj.org/toc/2076-3425Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in <sup>18</sup>F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.Hui ZhangEdward S. HuiPeng CaoHenry K. F. MakMDPI AGarticleamyloid-β depositionAlzheimer’s diseasecoupling between functional and structural networks<sup>18</sup>F-flutemetamol PET-CTresting-state functional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1535, p 1535 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyloid-β deposition Alzheimer’s disease coupling between functional and structural networks <sup>18</sup>F-flutemetamol PET-CT resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	amyloid-β deposition Alzheimer’s disease coupling between functional and structural networks <sup>18</sup>F-flutemetamol PET-CT resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hui Zhang Edward S. Hui Peng Cao Henry K. F. Mak Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
description	Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in <sup>18</sup>F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.
format	article
author	Hui Zhang Edward S. Hui Peng Cao Henry K. F. Mak
author_facet	Hui Zhang Edward S. Hui Peng Cao Henry K. F. Mak
author_sort	Hui Zhang
title	Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
title_short	Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
title_full	Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
title_fullStr	Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
title_full_unstemmed	Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease
title_sort	relationship between amyloid-β deposition and the coupling between structural and functional brain networks in patients with mild cognitive impairment and alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/211281462a6045ec9b58b9f5842d18d0
work_keys_str_mv	AT huizhang relationshipbetweenamyloidbdepositionandthecouplingbetweenstructuralandfunctionalbrainnetworksinpatientswithmildcognitiveimpairmentandalzheimersdisease AT edwardshui relationshipbetweenamyloidbdepositionandthecouplingbetweenstructuralandfunctionalbrainnetworksinpatientswithmildcognitiveimpairmentandalzheimersdisease AT pengcao relationshipbetweenamyloidbdepositionandthecouplingbetweenstructuralandfunctionalbrainnetworksinpatientswithmildcognitiveimpairmentandalzheimersdisease AT henrykfmak relationshipbetweenamyloidbdepositionandthecouplingbetweenstructuralandfunctionalbrainnetworksinpatientswithmildcognitiveimpairmentandalzheimersdisease
_version_	1718412824057741312

Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

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