Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cu...

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Autores principales:	Sun-Gyun Kim, Suho Lee, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2112da6461bf4b75bab1ac9b8695d0c5
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spelling	oai:doaj.org-article:2112da6461bf4b75bab1ac9b8695d0c52021-12-02T16:57:56ZTanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons10.1038/s41467-021-22908-42041-1723https://doaj.org/article/2112da6461bf4b75bab1ac9b8695d0c52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22908-4https://doaj.org/toc/2041-1723Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.Sun-Gyun KimSuho LeeYangsik KimJieun ParkDoyeon WooDayeon KimYan LiWangyong ShinHyunjeong KangChaehyun YookMinji LeeKyungdeok KimJunyeop Daniel RohJeseung RyuHwajin JungSeung Min UmEsther YangHyun KimJinju HanWon Do HeoEunjoon KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sun-Gyun Kim Suho Lee Yangsik Kim Jieun Park Doyeon Woo Dayeon Kim Yan Li Wangyong Shin Hyunjeong Kang Chaehyun Yook Minji Lee Kyungdeok Kim Junyeop Daniel Roh Jeseung Ryu Hwajin Jung Seung Min Um Esther Yang Hyun Kim Jinju Han Won Do Heo Eunjoon Kim Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
description	Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.
format	article
author	Sun-Gyun Kim Suho Lee Yangsik Kim Jieun Park Doyeon Woo Dayeon Kim Yan Li Wangyong Shin Hyunjeong Kang Chaehyun Yook Minji Lee Kyungdeok Kim Junyeop Daniel Roh Jeseung Ryu Hwajin Jung Seung Min Um Esther Yang Hyun Kim Jinju Han Won Do Heo Eunjoon Kim
author_facet	Sun-Gyun Kim Suho Lee Yangsik Kim Jieun Park Doyeon Woo Dayeon Kim Yan Li Wangyong Shin Hyunjeong Kang Chaehyun Yook Minji Lee Kyungdeok Kim Junyeop Daniel Roh Jeseung Ryu Hwajin Jung Seung Min Um Esther Yang Hyun Kim Jinju Han Won Do Heo Eunjoon Kim
author_sort	Sun-Gyun Kim
title	Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
title_short	Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
title_full	Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
title_fullStr	Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
title_full_unstemmed	Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
title_sort	tanc2-mediated mtor inhibition balances mtorc1/2 signaling in the developing mouse brain and human neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2112da6461bf4b75bab1ac9b8695d0c5
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Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

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