The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis

Abstract Cognitive side effects of anticholinergic medications in older adults are well documented. Whether these poor cognitive outcomes are observed in children has not been systematically investigated. We aimed to conduct a systematic review and meta-analysis on the associations between anticholi...

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Autores principales: Erica Ghezzi, Michelle Chan, Lisa M. Kalisch Ellett, Tyler J. Ross, Kathryn Richardson, Jun Ni Ho, Dayna Copley, Claire Steele, Hannah A. D. Keage
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2112dcbc345c4273b2427ae2b3966aab
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spelling oai:doaj.org-article:2112dcbc345c4273b2427ae2b3966aab2021-12-02T11:46:07ZThe effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis10.1038/s41598-020-80211-62045-2322https://doaj.org/article/2112dcbc345c4273b2427ae2b3966aab2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80211-6https://doaj.org/toc/2045-2322Abstract Cognitive side effects of anticholinergic medications in older adults are well documented. Whether these poor cognitive outcomes are observed in children has not been systematically investigated. We aimed to conduct a systematic review and meta-analysis on the associations between anticholinergic medication use and cognitive performance in children. Systematic review was conducted using Medline, PsychInfo, and Embase, identifying studies testing cognitive performance relative to the presence versus absence of anticholinergic medication(s) in children. We assessed effects overall, as well as relative to drug class, potency (low and high), cognitive domain, and duration of administration. The systematic search identified 46 articles suitable for meta-analysis. For the most part, random effects meta-analyses did not identify statistically significant associations between anticholinergic exposure and cognitive performance in children; the one exception was a small effect of anticholinergic anti-depressants being associated with better cognitive function (Hedges’ g = 0.24, 95% CI 0.06–0.42, p = 0.01). Anticholinergic medications do not appear to be associated with poor cognitive outcomes in children, as they do in older adults. The discrepancy in findings with older adults may be due to shorter durations of exposure in children, differences in study design (predominantly experimental studies in children rather than predominantly epidemiological in older adults), biological ageing (e.g. blood brain barrier integrity), along with less residual confounding due to minimal polypharmacy and comorbidity in children.Erica GhezziMichelle ChanLisa M. Kalisch EllettTyler J. RossKathryn RichardsonJun Ni HoDayna CopleyClaire SteeleHannah A. D. KeageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Erica Ghezzi
Michelle Chan
Lisa M. Kalisch Ellett
Tyler J. Ross
Kathryn Richardson
Jun Ni Ho
Dayna Copley
Claire Steele
Hannah A. D. Keage
The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
description Abstract Cognitive side effects of anticholinergic medications in older adults are well documented. Whether these poor cognitive outcomes are observed in children has not been systematically investigated. We aimed to conduct a systematic review and meta-analysis on the associations between anticholinergic medication use and cognitive performance in children. Systematic review was conducted using Medline, PsychInfo, and Embase, identifying studies testing cognitive performance relative to the presence versus absence of anticholinergic medication(s) in children. We assessed effects overall, as well as relative to drug class, potency (low and high), cognitive domain, and duration of administration. The systematic search identified 46 articles suitable for meta-analysis. For the most part, random effects meta-analyses did not identify statistically significant associations between anticholinergic exposure and cognitive performance in children; the one exception was a small effect of anticholinergic anti-depressants being associated with better cognitive function (Hedges’ g = 0.24, 95% CI 0.06–0.42, p = 0.01). Anticholinergic medications do not appear to be associated with poor cognitive outcomes in children, as they do in older adults. The discrepancy in findings with older adults may be due to shorter durations of exposure in children, differences in study design (predominantly experimental studies in children rather than predominantly epidemiological in older adults), biological ageing (e.g. blood brain barrier integrity), along with less residual confounding due to minimal polypharmacy and comorbidity in children.
format article
author Erica Ghezzi
Michelle Chan
Lisa M. Kalisch Ellett
Tyler J. Ross
Kathryn Richardson
Jun Ni Ho
Dayna Copley
Claire Steele
Hannah A. D. Keage
author_facet Erica Ghezzi
Michelle Chan
Lisa M. Kalisch Ellett
Tyler J. Ross
Kathryn Richardson
Jun Ni Ho
Dayna Copley
Claire Steele
Hannah A. D. Keage
author_sort Erica Ghezzi
title The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
title_short The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
title_full The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
title_fullStr The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
title_full_unstemmed The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
title_sort effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2112dcbc345c4273b2427ae2b3966aab
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