A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version wit...

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Autores principales: Yu Guo, Lisu Huang, Guangshun Zhang, Yanfeng Yao, He Zhou, Shu Shen, Bingqing Shen, Bo Li, Xin Li, Qian Zhang, Mingjie Chen, Da Chen, Jia Wu, Dan Fu, Xinxin Zeng, Mingfang Feng, Chunjiang Pi, Yuan Wang, Xingdong Zhou, Minmin Lu, Yarong Li, Yaohui Fang, Yun-Yueh Lu, Xue Hu, Shanshan Wang, Wanju Zhang, Ge Gao, Francisco Adrian, Qisheng Wang, Feng Yu, Yun Peng, Alexander G. Gabibov, Juan Min, Yuhui Wang, Heyu Huang, Alexey Stepanov, Wei Zhang, Yan Cai, Junwei Liu, Zhiming Yuan, Chen Zhang, Zhiyong Lou, Fei Deng, Hongkai Zhang, Chao Shan, Liang Schweizer, Kun Sun, Zihe Rao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/21135328ba984b23bc0472defd4545f7
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spelling oai:doaj.org-article:21135328ba984b23bc0472defd4545f72021-12-02T17:01:56ZA SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes10.1038/s41467-021-22926-22041-1723https://doaj.org/article/21135328ba984b23bc0472defd4545f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22926-2https://doaj.org/toc/2041-1723Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.Yu GuoLisu HuangGuangshun ZhangYanfeng YaoHe ZhouShu ShenBingqing ShenBo LiXin LiQian ZhangMingjie ChenDa ChenJia WuDan FuXinxin ZengMingfang FengChunjiang PiYuan WangXingdong ZhouMinmin LuYarong LiYaohui FangYun-Yueh LuXue HuShanshan WangWanju ZhangGe GaoFrancisco AdrianQisheng WangFeng YuYun PengAlexander G. GabibovJuan MinYuhui WangHeyu HuangAlexey StepanovWei ZhangYan CaiJunwei LiuZhiming YuanChen ZhangZhiyong LouFei DengHongkai ZhangChao ShanLiang SchweizerKun SunZihe RaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Guo
Lisu Huang
Guangshun Zhang
Yanfeng Yao
He Zhou
Shu Shen
Bingqing Shen
Bo Li
Xin Li
Qian Zhang
Mingjie Chen
Da Chen
Jia Wu
Dan Fu
Xinxin Zeng
Mingfang Feng
Chunjiang Pi
Yuan Wang
Xingdong Zhou
Minmin Lu
Yarong Li
Yaohui Fang
Yun-Yueh Lu
Xue Hu
Shanshan Wang
Wanju Zhang
Ge Gao
Francisco Adrian
Qisheng Wang
Feng Yu
Yun Peng
Alexander G. Gabibov
Juan Min
Yuhui Wang
Heyu Huang
Alexey Stepanov
Wei Zhang
Yan Cai
Junwei Liu
Zhiming Yuan
Chen Zhang
Zhiyong Lou
Fei Deng
Hongkai Zhang
Chao Shan
Liang Schweizer
Kun Sun
Zihe Rao
A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
description Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.
format article
author Yu Guo
Lisu Huang
Guangshun Zhang
Yanfeng Yao
He Zhou
Shu Shen
Bingqing Shen
Bo Li
Xin Li
Qian Zhang
Mingjie Chen
Da Chen
Jia Wu
Dan Fu
Xinxin Zeng
Mingfang Feng
Chunjiang Pi
Yuan Wang
Xingdong Zhou
Minmin Lu
Yarong Li
Yaohui Fang
Yun-Yueh Lu
Xue Hu
Shanshan Wang
Wanju Zhang
Ge Gao
Francisco Adrian
Qisheng Wang
Feng Yu
Yun Peng
Alexander G. Gabibov
Juan Min
Yuhui Wang
Heyu Huang
Alexey Stepanov
Wei Zhang
Yan Cai
Junwei Liu
Zhiming Yuan
Chen Zhang
Zhiyong Lou
Fei Deng
Hongkai Zhang
Chao Shan
Liang Schweizer
Kun Sun
Zihe Rao
author_facet Yu Guo
Lisu Huang
Guangshun Zhang
Yanfeng Yao
He Zhou
Shu Shen
Bingqing Shen
Bo Li
Xin Li
Qian Zhang
Mingjie Chen
Da Chen
Jia Wu
Dan Fu
Xinxin Zeng
Mingfang Feng
Chunjiang Pi
Yuan Wang
Xingdong Zhou
Minmin Lu
Yarong Li
Yaohui Fang
Yun-Yueh Lu
Xue Hu
Shanshan Wang
Wanju Zhang
Ge Gao
Francisco Adrian
Qisheng Wang
Feng Yu
Yun Peng
Alexander G. Gabibov
Juan Min
Yuhui Wang
Heyu Huang
Alexey Stepanov
Wei Zhang
Yan Cai
Junwei Liu
Zhiming Yuan
Chen Zhang
Zhiyong Lou
Fei Deng
Hongkai Zhang
Chao Shan
Liang Schweizer
Kun Sun
Zihe Rao
author_sort Yu Guo
title A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
title_short A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
title_full A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
title_fullStr A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
title_full_unstemmed A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
title_sort sars-cov-2 neutralizing antibody with extensive spike binding coverage and modified for optimal therapeutic outcomes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/21135328ba984b23bc0472defd4545f7
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