Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction

Fahmeeda Murtaza,1 Dana Toameh,2 Saed Al-Habib,3 Raj Maini,2 Hannah H Chiu,2,4,5 Eric S Tam,2,4,5 Sohel Somani2,4,5 1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; 2Uptown Eye Specialists, Brampton, Ontario, Canada; 3U Sculpt Plastic Surgery, Vaughan, Ontario, Canada;...

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Autores principales:	Murtaza F, Toameh D, Al-Habib S, Maini R, Chiu HH, Tam ES, Somani S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	broadband light intense pulsed light meibomian gland dysfunction dry eye disease Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2113c581a3384b8db1770a8602001d9f
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spelling	oai:doaj.org-article:2113c581a3384b8db1770a8602001d9f2021-12-02T18:51:31ZSafety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction1177-5483https://doaj.org/article/2113c581a3384b8db1770a8602001d9f2021-10-01T00:00:00Zhttps://www.dovepress.com/safety-and-efficacy-of-broadband-intense-pulsed-light-therapy-for-dry--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Fahmeeda Murtaza,1 Dana Toameh,2 Saed Al-Habib,3 Raj Maini,2 Hannah H Chiu,2,4,5 Eric S Tam,2,4,5 Sohel Somani2,4,5 1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; 2Uptown Eye Specialists, Brampton, Ontario, Canada; 3U Sculpt Plastic Surgery, Vaughan, Ontario, Canada; 4Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 5William Osler Health System, Brampton, Ontario, CanadaCorrespondence: Sohel SomaniUptown Eye Specialists, 401-7900 Hurontario Street, Brampton, Ontario, L6Y 0P6, CanadaTel +1 416 292-0330Fax +1 416 292-0331Email s.somani@utoronto.caBackground: BroadBand light intense pulsed light (BBL-IPL) therapy has shown to reduce hordeolum and blepharitis frequency. This study aims to evaluate the efficacy and safety of BBL-IPL therapy in patients with dry eye disease (DED) from meibomian gland dysfunction (MGD).Methods: This is a retrospective, consecutive case series of 48 patients with DED from MGD who underwent BBL-IPL therapy from October 2016 to January 2019 at a single, outpatient clinic in Ontario, Canada. Clinical outcomes included first and average non-invasive keratograph tear break-up times (NIKBUT), bulbar redness (BR) scores, tear meniscus heights (TMH), visual acuity (VA) and meibograph grades. Patient-reported outcomes included the Canadian dry eye assessment (CDEA) questionnaire and patient subjective assessment (PSA) scores. Outcomes were measured at baseline and after completion of 4 monthly BBL-IPL sessions.Results: The mean severity of dry eye symptoms as measured by the CDEA and PSA decreased significantly from 19.78 ± 9.62 to 12.08 ± 7.40 (p< 0.001) and from 7.65 ± 1.74 to 4.77 ± 2.03 (p< 0.001), respectively. Twenty-five percent of patients reported no dry eye symptoms after treatment. The meibograph grade improved significantly in both eyes (p< 0.001). Approximately 71.0% and 80.1% of patients had an improved meibograph grade in the right and left eye, respectively. Near-significant improvements were observed for BR scores and VA. There was also a trend towards improved first/average NIKBUT and TMH scores. No adverse events were noted.Conclusion: BBL-IPL appears to be an effective and safe treatment modality in improving dry eye symptoms and meibomian gland function in patients with DED from MGD.Keywords: BroadBand light, intense pulsed light, meibomian gland dysfunction, dry eye diseaseMurtaza FToameh DAl-Habib SMaini RChiu HHTam ESSomani SDove Medical Pressarticlebroadband lightintense pulsed lightmeibomian gland dysfunctiondry eye diseaseOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3983-3991 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	broadband light intense pulsed light meibomian gland dysfunction dry eye disease Ophthalmology RE1-994
spellingShingle	broadband light intense pulsed light meibomian gland dysfunction dry eye disease Ophthalmology RE1-994 Murtaza F Toameh D Al-Habib S Maini R Chiu HH Tam ES Somani S Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
description	Fahmeeda Murtaza,1 Dana Toameh,2 Saed Al-Habib,3 Raj Maini,2 Hannah H Chiu,2,4,5 Eric S Tam,2,4,5 Sohel Somani2,4,5 1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; 2Uptown Eye Specialists, Brampton, Ontario, Canada; 3U Sculpt Plastic Surgery, Vaughan, Ontario, Canada; 4Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 5William Osler Health System, Brampton, Ontario, CanadaCorrespondence: Sohel SomaniUptown Eye Specialists, 401-7900 Hurontario Street, Brampton, Ontario, L6Y 0P6, CanadaTel +1 416 292-0330Fax +1 416 292-0331Email s.somani@utoronto.caBackground: BroadBand light intense pulsed light (BBL-IPL) therapy has shown to reduce hordeolum and blepharitis frequency. This study aims to evaluate the efficacy and safety of BBL-IPL therapy in patients with dry eye disease (DED) from meibomian gland dysfunction (MGD).Methods: This is a retrospective, consecutive case series of 48 patients with DED from MGD who underwent BBL-IPL therapy from October 2016 to January 2019 at a single, outpatient clinic in Ontario, Canada. Clinical outcomes included first and average non-invasive keratograph tear break-up times (NIKBUT), bulbar redness (BR) scores, tear meniscus heights (TMH), visual acuity (VA) and meibograph grades. Patient-reported outcomes included the Canadian dry eye assessment (CDEA) questionnaire and patient subjective assessment (PSA) scores. Outcomes were measured at baseline and after completion of 4 monthly BBL-IPL sessions.Results: The mean severity of dry eye symptoms as measured by the CDEA and PSA decreased significantly from 19.78 ± 9.62 to 12.08 ± 7.40 (p< 0.001) and from 7.65 ± 1.74 to 4.77 ± 2.03 (p< 0.001), respectively. Twenty-five percent of patients reported no dry eye symptoms after treatment. The meibograph grade improved significantly in both eyes (p< 0.001). Approximately 71.0% and 80.1% of patients had an improved meibograph grade in the right and left eye, respectively. Near-significant improvements were observed for BR scores and VA. There was also a trend towards improved first/average NIKBUT and TMH scores. No adverse events were noted.Conclusion: BBL-IPL appears to be an effective and safe treatment modality in improving dry eye symptoms and meibomian gland function in patients with DED from MGD.Keywords: BroadBand light, intense pulsed light, meibomian gland dysfunction, dry eye disease
format	article
author	Murtaza F Toameh D Al-Habib S Maini R Chiu HH Tam ES Somani S
author_facet	Murtaza F Toameh D Al-Habib S Maini R Chiu HH Tam ES Somani S
author_sort	Murtaza F
title	Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
title_short	Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
title_full	Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
title_fullStr	Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
title_full_unstemmed	Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction
title_sort	safety and efficacy of broadband intense pulsed light therapy for dry eye disease with meibomian gland dysfunction
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2113c581a3384b8db1770a8602001d9f
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Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction

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