Some mechanisms of inflammation development in type 2 diabetes mellitus

Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity. The main source of inflammation in the early stages of the disease is visceral adipose tissue (VT). Macrophages are inn...

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Autores principales:	L. A. Bochkareva, L. V. Nedosugova, N. A. Petunina, M. Е. Теlnova, E. V. Goncharova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	inflammation type 2 diabetes mellitus insulin resistance adipose tissue macrophages Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/2118aaf5687d482aac22da2051bc2cc7
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spelling	oai:doaj.org-article:2118aaf5687d482aac22da2051bc2cc72021-11-14T09:00:23ZSome mechanisms of inflammation development in type 2 diabetes mellitus2072-03512072-037810.14341/DM12746https://doaj.org/article/2118aaf5687d482aac22da2051bc2cc72021-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12746https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity. The main source of inflammation in the early stages of the disease is visceral adipose tissue (VT). Macrophages are innate immune cells that are present in all peripheral tissues, including VT. Violation of the response of VT (MT) macrophages to changes in the microenvironment underlies aberrant inflammation and the development of local and systemic insulin resistance. The inflammatory activation of macrophages is regulated at several levels: stimulation of cell surface receptors, intracellular signaling, transcription, and metabolic levels. Which are activated by the transformation of macrophages along the pro-inflammatory or anti-inflammatory pathways. Such polarization of macrophages in modern immunology is divided into classical anti-inflammatory M1 polarization and alternative anti-inflammatory M2 polarization of macrophages. The M1 / M2 ratio of macrophages in the process of inflammation ensures the resolution of inflammation at different stages of its development. The review considers the main mechanisms involved in VT inflammation and the development of insulin resistance in T2DM, supported with the participation of immunocompetent cells, M1 / M2, as well as growth factors and humoral immunity factors secreted during this process.L. A. BochkarevaL. V. NedosugovaN. A. PetuninaM. Е. ТеlnovaE. V. GoncharovaEndocrinology Research Centrearticleinflammationtype 2 diabetes mellitusinsulin resistanceadipose tissuemacrophagesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 4, Pp 334-341 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	inflammation type 2 diabetes mellitus insulin resistance adipose tissue macrophages Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	inflammation type 2 diabetes mellitus insulin resistance adipose tissue macrophages Nutritional diseases. Deficiency diseases RC620-627 L. A. Bochkareva L. V. Nedosugova N. A. Petunina M. Е. Теlnova E. V. Goncharova Some mechanisms of inflammation development in type 2 diabetes mellitus
description	Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity. The main source of inflammation in the early stages of the disease is visceral adipose tissue (VT). Macrophages are innate immune cells that are present in all peripheral tissues, including VT. Violation of the response of VT (MT) macrophages to changes in the microenvironment underlies aberrant inflammation and the development of local and systemic insulin resistance. The inflammatory activation of macrophages is regulated at several levels: stimulation of cell surface receptors, intracellular signaling, transcription, and metabolic levels. Which are activated by the transformation of macrophages along the pro-inflammatory or anti-inflammatory pathways. Such polarization of macrophages in modern immunology is divided into classical anti-inflammatory M1 polarization and alternative anti-inflammatory M2 polarization of macrophages. The M1 / M2 ratio of macrophages in the process of inflammation ensures the resolution of inflammation at different stages of its development. The review considers the main mechanisms involved in VT inflammation and the development of insulin resistance in T2DM, supported with the participation of immunocompetent cells, M1 / M2, as well as growth factors and humoral immunity factors secreted during this process.
format	article
author	L. A. Bochkareva L. V. Nedosugova N. A. Petunina M. Е. Теlnova E. V. Goncharova
author_facet	L. A. Bochkareva L. V. Nedosugova N. A. Petunina M. Е. Теlnova E. V. Goncharova
author_sort	L. A. Bochkareva
title	Some mechanisms of inflammation development in type 2 diabetes mellitus
title_short	Some mechanisms of inflammation development in type 2 diabetes mellitus
title_full	Some mechanisms of inflammation development in type 2 diabetes mellitus
title_fullStr	Some mechanisms of inflammation development in type 2 diabetes mellitus
title_full_unstemmed	Some mechanisms of inflammation development in type 2 diabetes mellitus
title_sort	some mechanisms of inflammation development in type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/2118aaf5687d482aac22da2051bc2cc7
work_keys_str_mv	AT labochkareva somemechanismsofinflammationdevelopmentintype2diabetesmellitus AT lvnedosugova somemechanismsofinflammationdevelopmentintype2diabetesmellitus AT napetunina somemechanismsofinflammationdevelopmentintype2diabetesmellitus AT metelnova somemechanismsofinflammationdevelopmentintype2diabetesmellitus AT evgoncharova somemechanismsofinflammationdevelopmentintype2diabetesmellitus
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Some mechanisms of inflammation development in type 2 diabetes mellitus

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