The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.

The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro-inflammatory cytokines. Previously we found th...

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Autores principales:	Emma Hennessy, Julie O'Callaghan, Marlies J Mooij, Claire Legendre, Olga Camacho-Vanegas, Sandra C Camacho, Claire Adams, John A Martignetti, Fergal O'Gara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21193d5fc4c94b3cbef819c9f1935b9f
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spelling	oai:doaj.org-article:21193d5fc4c94b3cbef819c9f1935b9f2021-11-25T06:09:02ZThe impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.1932-620310.1371/journal.pone.0102200https://doaj.org/article/21193d5fc4c94b3cbef819c9f1935b9f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25010049/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro-inflammatory cytokines. Previously we found that statins modulate virulence phenotypes of the human pathogen Pseudomonas aeruginosa, and sought to investigate if simvastatin could alter the host response to this organism in lung epithelial cells. Simvastatin increased the expression of the P. aeruginosa target genes KLF2, KLF6, IL-8 and CCL20. Furthermore, both simvastatin and P. aeruginosa induced alternative splicing of KLF6. The novel effect of simvastatin on wtKLF6 expression was found to be responsible for induction of the KLF6 regulated genes CCL20 and iNOS. Simvastatin also increased the adhesion of P. aeruginosa to host cells, without altering invasion or cytotoxicity. This study demonstrated that simvastatin had several novel effects on the pulmonary cellular immune response.Emma HennessyJulie O'CallaghanMarlies J MooijClaire LegendreOlga Camacho-VanegasSandra C CamachoClaire AdamsJohn A MartignettiFergal O'GaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102200 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma Hennessy Julie O'Callaghan Marlies J Mooij Claire Legendre Olga Camacho-Vanegas Sandra C Camacho Claire Adams John A Martignetti Fergal O'Gara The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
description	The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro-inflammatory cytokines. Previously we found that statins modulate virulence phenotypes of the human pathogen Pseudomonas aeruginosa, and sought to investigate if simvastatin could alter the host response to this organism in lung epithelial cells. Simvastatin increased the expression of the P. aeruginosa target genes KLF2, KLF6, IL-8 and CCL20. Furthermore, both simvastatin and P. aeruginosa induced alternative splicing of KLF6. The novel effect of simvastatin on wtKLF6 expression was found to be responsible for induction of the KLF6 regulated genes CCL20 and iNOS. Simvastatin also increased the adhesion of P. aeruginosa to host cells, without altering invasion or cytotoxicity. This study demonstrated that simvastatin had several novel effects on the pulmonary cellular immune response.
format	article
author	Emma Hennessy Julie O'Callaghan Marlies J Mooij Claire Legendre Olga Camacho-Vanegas Sandra C Camacho Claire Adams John A Martignetti Fergal O'Gara
author_facet	Emma Hennessy Julie O'Callaghan Marlies J Mooij Claire Legendre Olga Camacho-Vanegas Sandra C Camacho Claire Adams John A Martignetti Fergal O'Gara
author_sort	Emma Hennessy
title	The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
title_short	The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
title_full	The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
title_fullStr	The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
title_full_unstemmed	The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.
title_sort	impact of simvastatin on pulmonary effectors of pseudomonas aeruginosa infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/21193d5fc4c94b3cbef819c9f1935b9f
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The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection.

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