Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy

BackgroundThe goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection.MethodsA total of 615 patients with ESCC who underwent esophagectomy were analyzed. Patients were divided into t...

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Autores principales:	Shu-jie Huang, Peng-fei Zhan, Shao-bin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	esophageal neoplasm mean corpuscular volume prognosis squamous cell carcinoma surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/211ceee5850245079b72509baaca02cc
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spelling	oai:doaj.org-article:211ceee5850245079b72509baaca02cc2021-11-16T05:18:13ZMean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy2234-943X10.3389/fonc.2021.752229https://doaj.org/article/211ceee5850245079b72509baaca02cc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.752229/fullhttps://doaj.org/toc/2234-943XBackgroundThe goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection.MethodsA total of 615 patients with ESCC who underwent esophagectomy were analyzed. Patients were divided into two groups according to the standard MCV: the high MCV group (>100 fl) and the low MCV group (≤100 fl). Survival analyses were performed to calculate overall survival (OS) and cancer-specific survival (CSS) and investigate the independent prognostic factors.ResultsFifty-one patients (8.3%) were in the high MCV group, and the other 564 patients (91.7%) were defined as the low MCV group. MCV was significantly correlated with sex, habitual alcohol or tobacco use, tumor length, body mass index, and multiple primary malignancies (P < 0.05). Elevated MCV was significantly correlated with poor survival in univariate and multivariate analyses. However, in subgroup analyses, MCV was found to be correlated with survival only in patients with alcohol or tobacco consumption and not in patients without alcohol or tobacco consumption.ConclusionsPretreatment MCV was correlated with survival in ESCC patients after esophagectomy. However, its prognostic value might only exist in patients with alcohol or tobacco consumption.Shu-jie HuangPeng-fei ZhanShao-bin ChenFrontiers Media S.A.articleesophageal neoplasmmean corpuscular volumeprognosissquamous cell carcinomasurgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal neoplasm mean corpuscular volume prognosis squamous cell carcinoma surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	esophageal neoplasm mean corpuscular volume prognosis squamous cell carcinoma surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shu-jie Huang Peng-fei Zhan Shao-bin Chen Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
description	BackgroundThe goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection.MethodsA total of 615 patients with ESCC who underwent esophagectomy were analyzed. Patients were divided into two groups according to the standard MCV: the high MCV group (>100 fl) and the low MCV group (≤100 fl). Survival analyses were performed to calculate overall survival (OS) and cancer-specific survival (CSS) and investigate the independent prognostic factors.ResultsFifty-one patients (8.3%) were in the high MCV group, and the other 564 patients (91.7%) were defined as the low MCV group. MCV was significantly correlated with sex, habitual alcohol or tobacco use, tumor length, body mass index, and multiple primary malignancies (P < 0.05). Elevated MCV was significantly correlated with poor survival in univariate and multivariate analyses. However, in subgroup analyses, MCV was found to be correlated with survival only in patients with alcohol or tobacco consumption and not in patients without alcohol or tobacco consumption.ConclusionsPretreatment MCV was correlated with survival in ESCC patients after esophagectomy. However, its prognostic value might only exist in patients with alcohol or tobacco consumption.
format	article
author	Shu-jie Huang Peng-fei Zhan Shao-bin Chen
author_facet	Shu-jie Huang Peng-fei Zhan Shao-bin Chen
author_sort	Shu-jie Huang
title	Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
title_short	Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
title_full	Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
title_fullStr	Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
title_full_unstemmed	Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
title_sort	mean corpuscular volume as a prognostic factor for patients with habitual alcohol or tobacco use after esophagectomy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/211ceee5850245079b72509baaca02cc
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Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy

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