Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.

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Autores principales:	Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/212054e33af24b80a55cb5e3dd710b36
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spelling	oai:doaj.org-article:212054e33af24b80a55cb5e3dd710b362021-12-02T14:30:27ZAcetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice10.1038/s41467-021-22501-92041-1723https://doaj.org/article/212054e33af24b80a55cb5e3dd710b362021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22501-9https://doaj.org/toc/2041-1723The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.Benjamin CaballeroMathieu BourdenxEnrique LuengoAntonio DiazPeter Dongmin SohnXu ChenChao WangYves R. JusteSusanne WegmannBindi PatelZapporah T. YoungSzu Yu KuoJose Antonio Rodriguez-NavarroHao ShaoManuela G. LopezCeleste M. KarchAlison M. GoateJason E. GestwickiBradley T. HymanLi GanAna Maria CuervoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
description	The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.
format	article
author	Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo
author_facet	Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo
author_sort	Benjamin Caballero
title	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
title_short	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
title_full	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
title_fullStr	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
title_full_unstemmed	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
title_sort	acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/212054e33af24b80a55cb5e3dd710b36
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

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