Spectroscopic evaluation of carcinogenesis in endometrial cancer

Abstract Carcinogenesis is a multifaceted process of cancer formation. The transformation of normal cells into cancerous ones may be difficult to determine at a very early stage. Therefore, methods enabling identification of initial changes caused by cancer require novel approaches. Although physica...

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Autores principales:	Joanna Depciuch, Edyta Barnaś, Joanna Skręt-Magierło, Andrzej Skręt, Ewa Kaznowska, Kornelia Łach, Paweł Jakubczyk, Jozef Cebulski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21210505dd6443fbb8bbbceb16f41803
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spelling	oai:doaj.org-article:21210505dd6443fbb8bbbceb16f418032021-12-02T16:56:02ZSpectroscopic evaluation of carcinogenesis in endometrial cancer10.1038/s41598-021-88640-72045-2322https://doaj.org/article/21210505dd6443fbb8bbbceb16f418032021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88640-7https://doaj.org/toc/2045-2322Abstract Carcinogenesis is a multifaceted process of cancer formation. The transformation of normal cells into cancerous ones may be difficult to determine at a very early stage. Therefore, methods enabling identification of initial changes caused by cancer require novel approaches. Although physical spectroscopic methods such as FT-Raman and Fourier Transform InfraRed (FTIR) are used to detect chemical changes in cancer tissues, their potential has not been investigated with respect to carcinogenesis. The study aimed to evaluate the usefulness of FT-Raman and FTIR spectroscopy as diagnostic methods of endometrial cancer carcinogenesis. The results indicated development of endometrial cancer was accompanied with chemical changes in nucleic acid, amide I and lipids in Raman spectra. FTIR spectra showed that tissues with development of carcinogenesis were characterized by changes in carbohydrates and amides vibrations. Principal component analysis and hierarchical cluster analysis of Raman spectra demonstrated similarity of tissues with cancer cells and lesions considered precursor of cancer (complex atypical hyperplasia), however they differed from the control samples. Pearson correlation test showed correlation between cancer and complex atypical hyperplasia tissues and between non-cancerous tissue samples. The results of the study indicate that Raman spectroscopy is more effective in assessing the development of carcinogenesis in endometrial cancer than FTIR.Joanna DepciuchEdyta BarnaśJoanna Skręt-MagierłoAndrzej SkrętEwa KaznowskaKornelia ŁachPaweł JakubczykJozef CebulskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Depciuch Edyta Barnaś Joanna Skręt-Magierło Andrzej Skręt Ewa Kaznowska Kornelia Łach Paweł Jakubczyk Jozef Cebulski Spectroscopic evaluation of carcinogenesis in endometrial cancer
description	Abstract Carcinogenesis is a multifaceted process of cancer formation. The transformation of normal cells into cancerous ones may be difficult to determine at a very early stage. Therefore, methods enabling identification of initial changes caused by cancer require novel approaches. Although physical spectroscopic methods such as FT-Raman and Fourier Transform InfraRed (FTIR) are used to detect chemical changes in cancer tissues, their potential has not been investigated with respect to carcinogenesis. The study aimed to evaluate the usefulness of FT-Raman and FTIR spectroscopy as diagnostic methods of endometrial cancer carcinogenesis. The results indicated development of endometrial cancer was accompanied with chemical changes in nucleic acid, amide I and lipids in Raman spectra. FTIR spectra showed that tissues with development of carcinogenesis were characterized by changes in carbohydrates and amides vibrations. Principal component analysis and hierarchical cluster analysis of Raman spectra demonstrated similarity of tissues with cancer cells and lesions considered precursor of cancer (complex atypical hyperplasia), however they differed from the control samples. Pearson correlation test showed correlation between cancer and complex atypical hyperplasia tissues and between non-cancerous tissue samples. The results of the study indicate that Raman spectroscopy is more effective in assessing the development of carcinogenesis in endometrial cancer than FTIR.
format	article
author	Joanna Depciuch Edyta Barnaś Joanna Skręt-Magierło Andrzej Skręt Ewa Kaznowska Kornelia Łach Paweł Jakubczyk Jozef Cebulski
author_facet	Joanna Depciuch Edyta Barnaś Joanna Skręt-Magierło Andrzej Skręt Ewa Kaznowska Kornelia Łach Paweł Jakubczyk Jozef Cebulski
author_sort	Joanna Depciuch
title	Spectroscopic evaluation of carcinogenesis in endometrial cancer
title_short	Spectroscopic evaluation of carcinogenesis in endometrial cancer
title_full	Spectroscopic evaluation of carcinogenesis in endometrial cancer
title_fullStr	Spectroscopic evaluation of carcinogenesis in endometrial cancer
title_full_unstemmed	Spectroscopic evaluation of carcinogenesis in endometrial cancer
title_sort	spectroscopic evaluation of carcinogenesis in endometrial cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21210505dd6443fbb8bbbceb16f41803
work_keys_str_mv	AT joannadepciuch spectroscopicevaluationofcarcinogenesisinendometrialcancer AT edytabarnas spectroscopicevaluationofcarcinogenesisinendometrialcancer AT joannaskretmagierło spectroscopicevaluationofcarcinogenesisinendometrialcancer AT andrzejskret spectroscopicevaluationofcarcinogenesisinendometrialcancer AT ewakaznowska spectroscopicevaluationofcarcinogenesisinendometrialcancer AT korneliałach spectroscopicevaluationofcarcinogenesisinendometrialcancer AT pawełjakubczyk spectroscopicevaluationofcarcinogenesisinendometrialcancer AT jozefcebulski spectroscopicevaluationofcarcinogenesisinendometrialcancer
_version_	1718382785898479616

Spectroscopic evaluation of carcinogenesis in endometrial cancer

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