Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride

Continuous exposure to sodium fluoride (NaF) imbalances the oxidative status in the body. The current study investigated the effect of the selenium/chitosan-folic (Se/chitosan-folic acid) novel metal complex on oxidative injury and tissue damage in the hepatic tissues of male rats exposed to (NaF)....

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Autores principales:	Samy M. El-Megharbel, Fawziah A. Al-Salmi, Moamen S. Refat, Reham Z. Hamza
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug metal complexes sodium fluoride (NaF) chitosan oxidative stress folic acid hepatic enzymes Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/2122dae49ece49bc89c592285b232151
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spelling	oai:doaj.org-article:2122dae49ece49bc89c592285b2321512021-11-25T17:18:44ZSelenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride10.3390/cryst111113542073-4352https://doaj.org/article/2122dae49ece49bc89c592285b2321512021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1354https://doaj.org/toc/2073-4352Continuous exposure to sodium fluoride (NaF) imbalances the oxidative status in the body. The current study investigated the effect of the selenium/chitosan-folic (Se/chitosan-folic acid) novel metal complex on oxidative injury and tissue damage in the hepatic tissues of male rats exposed to (NaF). Male rats received NaF (10.3 mg/kg) and Se/chitosan-folic acid (0.5 mg/Kg) orally for successive 30 days. Male rats exposed to NaF showed multi-histopathological alterations in the hepatic tissues including degenerative changes. NaF exposure elevated hepatic oxidative stress markers, lipid peroxidation, and lowered the antioxidant defense enzymes. Se/chitosan-folic acid novel complex supplementation significantly prevented hepatic injury, suppressed reactive oxygen species (ROS) generation and lipid peroxidation, and enhanced the antioxidant defense enzymes. In addition, Se/chitosan-folic acid supplementation improved the hepatic tissues of NaF-exposed male rats. In conclusion, the Se/chitosan-folic acid novel metal complex protects against NaF-induced oxidative injury and tissue injury in the hepatic tissues of male rats. The Se/chitosan-folic acid novel metal complex upregulated the hepatic tissues and enhanced the antioxidant defense enzymes in male rats.Samy M. El-MegharbelFawziah A. Al-SalmiMoamen S. RefatReham Z. HamzaMDPI AGarticledrug metal complexessodium fluoride (NaF)chitosanoxidative stressfolic acidhepatic enzymesCrystallographyQD901-999ENCrystals, Vol 11, Iss 1354, p 1354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug metal complexes sodium fluoride (NaF) chitosan oxidative stress folic acid hepatic enzymes Crystallography QD901-999
spellingShingle	drug metal complexes sodium fluoride (NaF) chitosan oxidative stress folic acid hepatic enzymes Crystallography QD901-999 Samy M. El-Megharbel Fawziah A. Al-Salmi Moamen S. Refat Reham Z. Hamza Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
description	Continuous exposure to sodium fluoride (NaF) imbalances the oxidative status in the body. The current study investigated the effect of the selenium/chitosan-folic (Se/chitosan-folic acid) novel metal complex on oxidative injury and tissue damage in the hepatic tissues of male rats exposed to (NaF). Male rats received NaF (10.3 mg/kg) and Se/chitosan-folic acid (0.5 mg/Kg) orally for successive 30 days. Male rats exposed to NaF showed multi-histopathological alterations in the hepatic tissues including degenerative changes. NaF exposure elevated hepatic oxidative stress markers, lipid peroxidation, and lowered the antioxidant defense enzymes. Se/chitosan-folic acid novel complex supplementation significantly prevented hepatic injury, suppressed reactive oxygen species (ROS) generation and lipid peroxidation, and enhanced the antioxidant defense enzymes. In addition, Se/chitosan-folic acid supplementation improved the hepatic tissues of NaF-exposed male rats. In conclusion, the Se/chitosan-folic acid novel metal complex protects against NaF-induced oxidative injury and tissue injury in the hepatic tissues of male rats. The Se/chitosan-folic acid novel metal complex upregulated the hepatic tissues and enhanced the antioxidant defense enzymes in male rats.
format	article
author	Samy M. El-Megharbel Fawziah A. Al-Salmi Moamen S. Refat Reham Z. Hamza
author_facet	Samy M. El-Megharbel Fawziah A. Al-Salmi Moamen S. Refat Reham Z. Hamza
author_sort	Samy M. El-Megharbel
title	Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
title_short	Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
title_full	Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
title_fullStr	Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
title_full_unstemmed	Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride
title_sort	selenium/chitosan-folic acid metal complex ameliorates hepatic damage and oxidative injury in male rats exposed to sodium fluoride
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2122dae49ece49bc89c592285b232151
work_keys_str_mv	AT samymelmegharbel seleniumchitosanfolicacidmetalcomplexameliorateshepaticdamageandoxidativeinjuryinmaleratsexposedtosodiumfluoride AT fawziahaalsalmi seleniumchitosanfolicacidmetalcomplexameliorateshepaticdamageandoxidativeinjuryinmaleratsexposedtosodiumfluoride AT moamensrefat seleniumchitosanfolicacidmetalcomplexameliorateshepaticdamageandoxidativeinjuryinmaleratsexposedtosodiumfluoride AT rehamzhamza seleniumchitosanfolicacidmetalcomplexameliorateshepaticdamageandoxidativeinjuryinmaleratsexposedtosodiumfluoride
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Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride

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