Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital

Objective: To explore the incidence and trend of ROP over the past 10 years. The secondary objective was to identify any association between clinical variables and threshold ROP. Materials and Methods: A cross-sectional, retrospective study of infants with <33 weeks’ gestational age (GA) or birt...

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Autores principales:	Kanya Chutasmit, Pimol Wongsiridej, Kanokwan Sommai, Supharat Siriwaeo, Pranchalee Insawang, Ratchada Kitsommart
Formato:	article
Lenguaje:	EN
Publicado:	Mahidol University 2021
Materias:	Incidence preterm infants retinopathy of prematurity screening threshold disease Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2122f93240fb4c5dafb4ca3813ce241c
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spelling	oai:doaj.org-article:2122f93240fb4c5dafb4ca3813ce241c2021-12-01T10:07:36ZIncidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital10.33192/Smj.2021.1012228-8082https://doaj.org/article/2122f93240fb4c5dafb4ca3813ce241c2021-12-01T00:00:00Zhttps://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/255151https://doaj.org/toc/2228-8082 Objective: To explore the incidence and trend of ROP over the past 10 years. The secondary objective was to identify any association between clinical variables and threshold ROP. Materials and Methods: A cross-sectional, retrospective study of infants with <33 weeks’ gestational age (GA) or birth weight (BW) ≤1,500g were screened for ROP between January 2010 and December 2019 Infants who had threshold ROP, labelled as the T-group, were compared against non-threshold infants (either normal or prethreshold ROP), or the NT-group. Results: Of the 1,247 infants who were screened for ROP, 174 (14%) tested positive for ROP while 26 (2.1%) had threshold ROP. Infants who had ROP had a mean ±standard deviation (SD) GA 27.2 ± 2.2 weeks and 115 (66.1%) were <1000g at birth. Advanced GA was independently associated with lower risk of threshold ROP [adjusted odds ratio (95% confidence interval, CI); 0.71 (0.52, 0.98), p=0.04]. There was no difference in respiratory and hemodynamic outcomes between the T and NT-group, except for longer hospitalization (median [P25, P75]; 121[106.3, 160.5] and 93.5[72.3, 129] days, p=0.003]. Culture-positive septicemia was independently associated with threshold ROP [adjusted odds ratio (95% CI); 4.48 (1.72, 11.68), p=0.002]. Conclusion: The incidence of different stages of ROP in infants was 14% and 2.1% for severe ROP which required treatment. Lower GA and positive-culture septicemia was associated with a higher incidence of severe ROP. Kanya ChutasmitPimol WongsiridejKanokwan SommaiSupharat SiriwaeoPranchalee InsawangRatchada KitsommartMahidol UniversityarticleIncidencepreterm infantsretinopathy of prematurityscreeningthreshold diseaseMedicine (General)R5-920ENSiriraj Medical Journal, Vol 73, Iss 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Incidence preterm infants retinopathy of prematurity screening threshold disease Medicine (General) R5-920
spellingShingle	Incidence preterm infants retinopathy of prematurity screening threshold disease Medicine (General) R5-920 Kanya Chutasmit Pimol Wongsiridej Kanokwan Sommai Supharat Siriwaeo Pranchalee Insawang Ratchada Kitsommart Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
description	Objective: To explore the incidence and trend of ROP over the past 10 years. The secondary objective was to identify any association between clinical variables and threshold ROP. Materials and Methods: A cross-sectional, retrospective study of infants with <33 weeks’ gestational age (GA) or birth weight (BW) ≤1,500g were screened for ROP between January 2010 and December 2019 Infants who had threshold ROP, labelled as the T-group, were compared against non-threshold infants (either normal or prethreshold ROP), or the NT-group. Results: Of the 1,247 infants who were screened for ROP, 174 (14%) tested positive for ROP while 26 (2.1%) had threshold ROP. Infants who had ROP had a mean ±standard deviation (SD) GA 27.2 ± 2.2 weeks and 115 (66.1%) were <1000g at birth. Advanced GA was independently associated with lower risk of threshold ROP [adjusted odds ratio (95% confidence interval, CI); 0.71 (0.52, 0.98), p=0.04]. There was no difference in respiratory and hemodynamic outcomes between the T and NT-group, except for longer hospitalization (median [P25, P75]; 121[106.3, 160.5] and 93.5[72.3, 129] days, p=0.003]. Culture-positive septicemia was independently associated with threshold ROP [adjusted odds ratio (95% CI); 4.48 (1.72, 11.68), p=0.002]. Conclusion: The incidence of different stages of ROP in infants was 14% and 2.1% for severe ROP which required treatment. Lower GA and positive-culture septicemia was associated with a higher incidence of severe ROP.
format	article
author	Kanya Chutasmit Pimol Wongsiridej Kanokwan Sommai Supharat Siriwaeo Pranchalee Insawang Ratchada Kitsommart
author_facet	Kanya Chutasmit Pimol Wongsiridej Kanokwan Sommai Supharat Siriwaeo Pranchalee Insawang Ratchada Kitsommart
author_sort	Kanya Chutasmit
title	Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
title_short	Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
title_full	Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
title_fullStr	Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
title_full_unstemmed	Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital
title_sort	incidence and risk factors of retinopathy of prematurity, a 10-year experience of a single-center, referral, hospital
publisher	Mahidol University
publishDate	2021
url	https://doaj.org/article/2122f93240fb4c5dafb4ca3813ce241c
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Incidence and Risk Factors of Retinopathy of Prematurity, a 10-year Experience of a Single-center, Referral, Hospital

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