Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?

ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular protozoan parasite with a broad range of intermediate hosts, including humans and rodents. In many hosts, T. gondii establishes a latent long-term infection by converting from its rapidly dividing or lytic form to its slowly replicating and e...

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Autores principales:	Hannah J. Johnson, Anita A. Koshy
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Toxoplasma gondii behavior central nervous system infections human murine neurodegeneration Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2125f5f47b044ef9b9e9dc8676d43b7e
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spelling	oai:doaj.org-article:2125f5f47b044ef9b9e9dc8676d43b7e2021-11-15T15:57:03ZLatent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?10.1128/mBio.02164-192150-7511https://doaj.org/article/2125f5f47b044ef9b9e9dc8676d43b7e2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02164-19https://doaj.org/toc/2150-7511ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular protozoan parasite with a broad range of intermediate hosts, including humans and rodents. In many hosts, T. gondii establishes a latent long-term infection by converting from its rapidly dividing or lytic form to its slowly replicating and encysting form. In humans and rodents, the major organ for encystment is the central nervous system (CNS), which has led many to investigate how this persistent CNS infection might influence rodent and human behavior and, more recently, neurodegenerative diseases. Given the interest in this topic, here we seek to take a global approach to the data for and against the effects of latent T. gondii on behavior and neurodegeneration and the proposed mechanisms that might underlie behavior modifications.Hannah J. JohnsonAnita A. KoshyAmerican Society for MicrobiologyarticleToxoplasma gondiibehaviorcentral nervous system infectionshumanmurineneurodegenerationMicrobiologyQR1-502ENmBio, Vol 11, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Toxoplasma gondii behavior central nervous system infections human murine neurodegeneration Microbiology QR1-502
spellingShingle	Toxoplasma gondii behavior central nervous system infections human murine neurodegeneration Microbiology QR1-502 Hannah J. Johnson Anita A. Koshy Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
description	ABSTRACT Toxoplasma gondii is a ubiquitous, intracellular protozoan parasite with a broad range of intermediate hosts, including humans and rodents. In many hosts, T. gondii establishes a latent long-term infection by converting from its rapidly dividing or lytic form to its slowly replicating and encysting form. In humans and rodents, the major organ for encystment is the central nervous system (CNS), which has led many to investigate how this persistent CNS infection might influence rodent and human behavior and, more recently, neurodegenerative diseases. Given the interest in this topic, here we seek to take a global approach to the data for and against the effects of latent T. gondii on behavior and neurodegeneration and the proposed mechanisms that might underlie behavior modifications.
format	article
author	Hannah J. Johnson Anita A. Koshy
author_facet	Hannah J. Johnson Anita A. Koshy
author_sort	Hannah J. Johnson
title	Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
title_short	Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
title_full	Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
title_fullStr	Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
title_full_unstemmed	Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?
title_sort	latent toxoplasmosis effects on rodents and humans: how much is real and how much is media hype?
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/2125f5f47b044ef9b9e9dc8676d43b7e
work_keys_str_mv	AT hannahjjohnson latenttoxoplasmosiseffectsonrodentsandhumanshowmuchisrealandhowmuchismediahype AT anitaakoshy latenttoxoplasmosiseffectsonrodentsandhumanshowmuchisrealandhowmuchismediahype
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Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?

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