The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.

The preservation of physiological transport of ions and water content is particularly important for maintaining the skin barrier, touch and pain stimuli, as well as the initiation of skin regeneration processes, especially after treatments associated with breaking skin continuity and wound healing d...

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Autores principales:	Iga Hołyńska-Iwan, Paulina Smyk, Agnieszka Chrustek, Dorota Olszewska-Słonina, Karolina Szewczyk-Golec
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/212b0f538c304f29b4d433ae505f94ea
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spelling	oai:doaj.org-article:212b0f538c304f29b4d433ae505f94ea2021-12-02T20:18:19ZThe influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.1932-620310.1371/journal.pone.0255825https://doaj.org/article/212b0f538c304f29b4d433ae505f94ea2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255825https://doaj.org/toc/1932-6203The preservation of physiological transport of ions and water content is particularly important for maintaining the skin barrier, touch and pain stimuli, as well as the initiation of skin regeneration processes, especially after treatments associated with breaking skin continuity and wound healing difficulties. The aim of the study was to assess changes in ion transport, measured as values of transepithelial electric resistance and potential difference in stationary conditions and during mechanical-chemical stimulations, depending on the hydration status of isolated rabbit skin specimens. The specimens were divided into five groups: control (n = 22), dehydrated in 10% NaCl (n = 30), rehydrated after dehydration (n = 26), dried at 37°C (n = 26), and rehydrated after drying (n = 25). Dehydrated tissue samples showed altered resistance compared to the control; this change was maintained regardless of rehydration. In the dehydrated samples, changes in the measured electric potential were also noted, which returned to values comparable with the control after rehydration. Dehydrated skin, regardless of the cause of dehydration, responds with changes in the transport of sodium and chloride ions and the altered cellular microenvironment. It could influence the perception of stimuli, particularly pain, and slow down the regeneration processes.Iga Hołyńska-IwanPaulina SmykAgnieszka ChrustekDorota Olszewska-SłoninaKarolina Szewczyk-GolecPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iga Hołyńska-Iwan Paulina Smyk Agnieszka Chrustek Dorota Olszewska-Słonina Karolina Szewczyk-Golec The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
description	The preservation of physiological transport of ions and water content is particularly important for maintaining the skin barrier, touch and pain stimuli, as well as the initiation of skin regeneration processes, especially after treatments associated with breaking skin continuity and wound healing difficulties. The aim of the study was to assess changes in ion transport, measured as values of transepithelial electric resistance and potential difference in stationary conditions and during mechanical-chemical stimulations, depending on the hydration status of isolated rabbit skin specimens. The specimens were divided into five groups: control (n = 22), dehydrated in 10% NaCl (n = 30), rehydrated after dehydration (n = 26), dried at 37°C (n = 26), and rehydrated after drying (n = 25). Dehydrated tissue samples showed altered resistance compared to the control; this change was maintained regardless of rehydration. In the dehydrated samples, changes in the measured electric potential were also noted, which returned to values comparable with the control after rehydration. Dehydrated skin, regardless of the cause of dehydration, responds with changes in the transport of sodium and chloride ions and the altered cellular microenvironment. It could influence the perception of stimuli, particularly pain, and slow down the regeneration processes.
format	article
author	Iga Hołyńska-Iwan Paulina Smyk Agnieszka Chrustek Dorota Olszewska-Słonina Karolina Szewczyk-Golec
author_facet	Iga Hołyńska-Iwan Paulina Smyk Agnieszka Chrustek Dorota Olszewska-Słonina Karolina Szewczyk-Golec
author_sort	Iga Hołyńska-Iwan
title	The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
title_short	The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
title_full	The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
title_fullStr	The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
title_full_unstemmed	The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.
title_sort	influence of hydration status on ion transport in the rabbit (oryctolagus cuniculus) skin-an in vitro study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/212b0f538c304f29b4d433ae505f94ea
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The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.

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