CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production of single sex offspring that can be repurposed for...

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Autores principales:	Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/212d0ada3e1b4efc91787d0acfd6cf85
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spelling	oai:doaj.org-article:212d0ada3e1b4efc91787d0acfd6cf852021-12-05T12:22:59ZCRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes10.1038/s41467-021-27227-22041-1723https://doaj.org/article/212d0ada3e1b4efc91787d0acfd6cf852021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27227-2https://doaj.org/toc/2041-1723In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production of single sex offspring that can be repurposed for use in multiple organisms.Charlotte DouglasValdone MaciulyteJasmin ZohrenDaniel M. SnellShantha K. MahadevaiahObah A. OjarikrePeter J. I. EllisJames M. A. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charlotte Douglas Valdone Maciulyte Jasmin Zohren Daniel M. Snell Shantha K. Mahadevaiah Obah A. Ojarikre Peter J. I. Ellis James M. A. Turner CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
description	In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production of single sex offspring that can be repurposed for use in multiple organisms.
format	article
author	Charlotte Douglas Valdone Maciulyte Jasmin Zohren Daniel M. Snell Shantha K. Mahadevaiah Obah A. Ojarikre Peter J. I. Ellis James M. A. Turner
author_facet	Charlotte Douglas Valdone Maciulyte Jasmin Zohren Daniel M. Snell Shantha K. Mahadevaiah Obah A. Ojarikre Peter J. I. Ellis James M. A. Turner
author_sort	Charlotte Douglas
title	CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
title_short	CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
title_full	CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
title_fullStr	CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
title_full_unstemmed	CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
title_sort	crispr-cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/212d0ada3e1b4efc91787d0acfd6cf85
work_keys_str_mv	AT charlottedouglas crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT valdonemaciulyte crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT jasminzohren crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT danielmsnell crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT shanthakmahadevaiah crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT obahaojarikre crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT peterjiellis crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes AT jamesmaturner crisprcas9effectorsfacilitategenerationofsinglesexlittersandsexspecificphenotypes
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CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

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