Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.

Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.

Proopiomelanocortin-derived peptides exert pleiotropic effects via binding to melanocortin receptors (MCR). MCR-subtypes have been detected in cartilage and bone and mediate an increasing number of effects in diathrodial joints. This study aims to determine the role of MC1-receptors (MC1) in joint p...

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Autores principales: Julia Lorenz, Elisabeth Seebach, Gerit Hackmayer, Carina Greth, Richard J Bauer, Kerstin Kleinschmidt, Dominik Bettenworth, Markus Böhm, Joachim Grifka, Susanne Grässel
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/212d924d6f7c42a3bd04b4a9c2b5fea8
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