LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE

Syngeneic splenocyte transplantation leads to lymphopenia development in intact mice owing to decreased proliferative activity of bone marrow hematopoietic progenitor cells. In the mice with induced chronic graft-versus-host disease (cGVHD) transfer of syngeneic lymphocytes has little or no effect o...

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Autores principales:	E. V. Goiman, V. O. Tkachev, O. T. Kudayeva, O. P. Kolesnikova, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	lymphopenia chronic graft versus host disease homeostatic proliferation autoimmune glomerulonephritis Science Q
Acceso en línea:	https://doaj.org/article/212ed1a9a6224f47b2f56d111646a5fa
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spelling	oai:doaj.org-article:212ed1a9a6224f47b2f56d111646a5fa2021-11-23T06:14:20ZLYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE2541-94202587-9596https://doaj.org/article/212ed1a9a6224f47b2f56d111646a5fa2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/932https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Syngeneic splenocyte transplantation leads to lymphopenia development in intact mice owing to decreased proliferative activity of bone marrow hematopoietic progenitor cells. In the mice with induced chronic graft-versus-host disease (cGVHD) transfer of syngeneic lymphocytes has little or no effect on the level of already existing lymphopenia, but increases its duration. These results are in close agreement with the received evidences that transfer of syngeneic cells increases frequency of autoimmune glomerulonephritis at cGVHD. Thus, results of research speak in favor of conclusion that lymphopenia and initiated by it homeostatic proliferation play a pathogenetic role in the development of autoimmune reactions at cGVHD.E. V. GoimanV. O. TkachevO. T. KudayevaO. P. KolesnikovaV. A. KozlovScientific Сentre for Family Health and Human Reproduction Problemsarticlelymphopeniachronic graft versus host diseasehomeostatic proliferationautoimmune glomerulonephritisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 267-270 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphopenia chronic graft versus host disease homeostatic proliferation autoimmune glomerulonephritis Science Q
spellingShingle	lymphopenia chronic graft versus host disease homeostatic proliferation autoimmune glomerulonephritis Science Q E. V. Goiman V. O. Tkachev O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
description	Syngeneic splenocyte transplantation leads to lymphopenia development in intact mice owing to decreased proliferative activity of bone marrow hematopoietic progenitor cells. In the mice with induced chronic graft-versus-host disease (cGVHD) transfer of syngeneic lymphocytes has little or no effect on the level of already existing lymphopenia, but increases its duration. These results are in close agreement with the received evidences that transfer of syngeneic cells increases frequency of autoimmune glomerulonephritis at cGVHD. Thus, results of research speak in favor of conclusion that lymphopenia and initiated by it homeostatic proliferation play a pathogenetic role in the development of autoimmune reactions at cGVHD.
format	article
author	E. V. Goiman V. O. Tkachev O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov
author_facet	E. V. Goiman V. O. Tkachev O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov
author_sort	E. V. Goiman
title	LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
title_short	LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
title_full	LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
title_fullStr	LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
title_full_unstemmed	LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE
title_sort	lymphopenia as a factor involved in the autoimmunity development in murine graft vs. host disease
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/212ed1a9a6224f47b2f56d111646a5fa
work_keys_str_mv	AT evgoiman lymphopeniaasafactorinvolvedintheautoimmunitydevelopmentinmurinegraftvshostdisease AT votkachev lymphopeniaasafactorinvolvedintheautoimmunitydevelopmentinmurinegraftvshostdisease AT otkudayeva lymphopeniaasafactorinvolvedintheautoimmunitydevelopmentinmurinegraftvshostdisease AT opkolesnikova lymphopeniaasafactorinvolvedintheautoimmunitydevelopmentinmurinegraftvshostdisease AT vakozlov lymphopeniaasafactorinvolvedintheautoimmunitydevelopmentinmurinegraftvshostdisease
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LYMPHOPENIA AS A FACTOR INVOLVED IN THE AUTOIMMUNITY DEVELOPMENT IN MURINE GRAFT VS. HOST DISEASE

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