MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer

Colorectal cancer (CRC) is a global public health issue with increasing prevalence. MicroRNA-934 (miR-934) is a kind of non-coding RNA involved in the regulation of diverse cancers. Though previous researches have revealed part of association between miR-934 and CRC, the role of miR-934 in CRC patho...

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Autores principales:	Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	angiogenesis btg2 cell proliferation cell migration mir-934 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/2131ee4fccd543339db7b913cfa390aa
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spelling	oai:doaj.org-article:2131ee4fccd543339db7b913cfa390aa2021-11-04T15:51:54ZMicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer2165-59792165-598710.1080/21655979.2021.1996505https://doaj.org/article/2131ee4fccd543339db7b913cfa390aa2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996505https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Colorectal cancer (CRC) is a global public health issue with increasing prevalence. MicroRNA-934 (miR-934) is a kind of non-coding RNA involved in the regulation of diverse cancers. Though previous researches have revealed part of association between miR-934 and CRC, the role of miR-934 in CRC pathogenesis has not been completely explored yet. In this study, we aim to investigate the effect of miR-934 on cell proliferation, migration, invasion and angiogenesis in CRC. Accordingly, miR-934 was found to be over-expressed in SW480 and HCT116 cells, two typical CRC cell lines. Meanwhile, miR-934 knockdown significantly inhibited cell proliferation and induced cell cycle arrest in SW480 and HCT116 cells. It was further validated that miR-934 knockdown displayed an inhibitory effect on cell migration and invasion in SW480 and HCT116 cells. Additionally, miR-934 deficiency markedly decreased VEGF expression in SW480 and HCT116 cells and suppressed capability of CRC cells to promote tube formation in vascular endothelial cells, which suggests the pro-angiogenesis role of miR-934 in vitro. Dual luciferase reporter assay further showed that miR-934 directly bound to B-cell translocation gene 2 (BTG2). BTG2 knockdown reversed the inhibitory effect of miR-934 silencing on cell proliferation, migration, invasion, and angiogenesis in SW480 and HCT116 cells. In summary, this study suggests that miR-934 facilitates CRC progression by targeting BTG2, and further highlights the role of miR-934 in pathogenesis of CRC.Bo LiXianyi LiuGuogang WuJiawen LiuShouliang CaiFuxin WangChunyu YangJisheng LiuTaylor & Francis Grouparticleangiogenesisbtg2cell proliferationcell migrationmir-934BiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis btg2 cell proliferation cell migration mir-934 Biotechnology TP248.13-248.65
spellingShingle	angiogenesis btg2 cell proliferation cell migration mir-934 Biotechnology TP248.13-248.65 Bo Li Xianyi Liu Guogang Wu Jiawen Liu Shouliang Cai Fuxin Wang Chunyu Yang Jisheng Liu MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
description	Colorectal cancer (CRC) is a global public health issue with increasing prevalence. MicroRNA-934 (miR-934) is a kind of non-coding RNA involved in the regulation of diverse cancers. Though previous researches have revealed part of association between miR-934 and CRC, the role of miR-934 in CRC pathogenesis has not been completely explored yet. In this study, we aim to investigate the effect of miR-934 on cell proliferation, migration, invasion and angiogenesis in CRC. Accordingly, miR-934 was found to be over-expressed in SW480 and HCT116 cells, two typical CRC cell lines. Meanwhile, miR-934 knockdown significantly inhibited cell proliferation and induced cell cycle arrest in SW480 and HCT116 cells. It was further validated that miR-934 knockdown displayed an inhibitory effect on cell migration and invasion in SW480 and HCT116 cells. Additionally, miR-934 deficiency markedly decreased VEGF expression in SW480 and HCT116 cells and suppressed capability of CRC cells to promote tube formation in vascular endothelial cells, which suggests the pro-angiogenesis role of miR-934 in vitro. Dual luciferase reporter assay further showed that miR-934 directly bound to B-cell translocation gene 2 (BTG2). BTG2 knockdown reversed the inhibitory effect of miR-934 silencing on cell proliferation, migration, invasion, and angiogenesis in SW480 and HCT116 cells. In summary, this study suggests that miR-934 facilitates CRC progression by targeting BTG2, and further highlights the role of miR-934 in pathogenesis of CRC.
format	article
author	Bo Li Xianyi Liu Guogang Wu Jiawen Liu Shouliang Cai Fuxin Wang Chunyu Yang Jisheng Liu
author_facet	Bo Li Xianyi Liu Guogang Wu Jiawen Liu Shouliang Cai Fuxin Wang Chunyu Yang Jisheng Liu
author_sort	Bo Li
title	MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
title_short	MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
title_full	MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
title_fullStr	MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
title_full_unstemmed	MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer
title_sort	microrna-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting b-cell translocation gene 2: running title: mir934 facilitates the progression of colorectal cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/2131ee4fccd543339db7b913cfa390aa
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MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2: Running title: miR934 facilitates the progression of colorectal cancer

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