Brain age prediction using deep learning uncovers associated sequence variants

Machine learning algorithms can be trained to estimate age from brain structural MRI. Here, the authors introduce a new deep-learning-based age prediction approach, and then carry out a GWAS of the difference between predicted and chronological age, revealing two associated variants.

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Autores principales:	B. A. Jonsson, G. Bjornsdottir, T. E. Thorgeirsson, L. M. Ellingsen, G. Bragi Walters, D. F. Gudbjartsson, H. Stefansson, K. Stefansson, M. O. Ulfarsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/213453bfd3e54ce99b57019d4343efca
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spelling	oai:doaj.org-article:213453bfd3e54ce99b57019d4343efca2021-12-02T17:01:41ZBrain age prediction using deep learning uncovers associated sequence variants10.1038/s41467-019-13163-92041-1723https://doaj.org/article/213453bfd3e54ce99b57019d4343efca2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13163-9https://doaj.org/toc/2041-1723Machine learning algorithms can be trained to estimate age from brain structural MRI. Here, the authors introduce a new deep-learning-based age prediction approach, and then carry out a GWAS of the difference between predicted and chronological age, revealing two associated variants.B. A. JonssonG. BjornsdottirT. E. ThorgeirssonL. M. EllingsenG. Bragi WaltersD. F. GudbjartssonH. StefanssonK. StefanssonM. O. UlfarssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q B. A. Jonsson G. Bjornsdottir T. E. Thorgeirsson L. M. Ellingsen G. Bragi Walters D. F. Gudbjartsson H. Stefansson K. Stefansson M. O. Ulfarsson Brain age prediction using deep learning uncovers associated sequence variants
description	Machine learning algorithms can be trained to estimate age from brain structural MRI. Here, the authors introduce a new deep-learning-based age prediction approach, and then carry out a GWAS of the difference between predicted and chronological age, revealing two associated variants.
format	article
author	B. A. Jonsson G. Bjornsdottir T. E. Thorgeirsson L. M. Ellingsen G. Bragi Walters D. F. Gudbjartsson H. Stefansson K. Stefansson M. O. Ulfarsson
author_facet	B. A. Jonsson G. Bjornsdottir T. E. Thorgeirsson L. M. Ellingsen G. Bragi Walters D. F. Gudbjartsson H. Stefansson K. Stefansson M. O. Ulfarsson
author_sort	B. A. Jonsson
title	Brain age prediction using deep learning uncovers associated sequence variants
title_short	Brain age prediction using deep learning uncovers associated sequence variants
title_full	Brain age prediction using deep learning uncovers associated sequence variants
title_fullStr	Brain age prediction using deep learning uncovers associated sequence variants
title_full_unstemmed	Brain age prediction using deep learning uncovers associated sequence variants
title_sort	brain age prediction using deep learning uncovers associated sequence variants
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/213453bfd3e54ce99b57019d4343efca
work_keys_str_mv	AT bajonsson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT gbjornsdottir brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT tethorgeirsson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT lmellingsen brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT gbragiwalters brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT dfgudbjartsson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT hstefansson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT kstefansson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants AT moulfarsson brainagepredictionusingdeeplearninguncoversassociatedsequencevariants
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Brain age prediction using deep learning uncovers associated sequence variants

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