The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)

Abstract There is a large controversy as to whether nitrous oxide (N2O) added to the anaesthetic gas mixture is harmful or harmless for postoperative cognitive function recovery. We performed a nested study in the ENIGMA-II trial and compared postoperative neurocognitive recovery of patients randoml...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guy Haller, Matthew T. V. Chan, Christophe Combescure, Ursula Lopez, Isabelle Pichon, Marc Licker, Roxane Fournier, Paul Myles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2135068b5f3a4e048e880ef43b129637
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2135068b5f3a4e048e880ef43b129637
record_format	dspace
spelling	oai:doaj.org-article:2135068b5f3a4e048e880ef43b1296372021-12-02T18:25:03ZThe international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)10.1038/s41598-021-91014-82045-2322https://doaj.org/article/2135068b5f3a4e048e880ef43b1296372021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91014-8https://doaj.org/toc/2045-2322Abstract There is a large controversy as to whether nitrous oxide (N2O) added to the anaesthetic gas mixture is harmful or harmless for postoperative cognitive function recovery. We performed a nested study in the ENIGMA-II trial and compared postoperative neurocognitive recovery of patients randomly receiving N2O (70%) or Air (70%) in 30% O2 during anesthesia. We included adults having non cardiac surgery. We compared recovery scores for episodic memory, decision making/processing speed and executive functions measured with the computerised Cambridge Neuropsychological Test Automated Battery (CANTAB). Assessments were performed at baseline, seven and ninety days. At first interim analysis, following recruitment of 140 participants, the trial was suspended. We found that the mean (95%CI) changes of scores for episodic memory were in the Pocock futility boundaries. Decision making/processing speed did not differ either between groups (P > 0.182). But for executive functions at seven days, the mean number (95% CI) of problems successfully solved and the number of correct box choices made was higher in the N2O group, P = 0.029. N2O with the limitations of an interim analysis appears to have no harmful effect on cognitive functions (memory/processing speed). It may improve the early recovery process of executive functions. This preliminary finding warrants further investigations.Guy HallerMatthew T. V. ChanChristophe CombescureUrsula LopezIsabelle PichonMarc LickerRoxane FournierPaul MylesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guy Haller Matthew T. V. Chan Christophe Combescure Ursula Lopez Isabelle Pichon Marc Licker Roxane Fournier Paul Myles The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
description	Abstract There is a large controversy as to whether nitrous oxide (N2O) added to the anaesthetic gas mixture is harmful or harmless for postoperative cognitive function recovery. We performed a nested study in the ENIGMA-II trial and compared postoperative neurocognitive recovery of patients randomly receiving N2O (70%) or Air (70%) in 30% O2 during anesthesia. We included adults having non cardiac surgery. We compared recovery scores for episodic memory, decision making/processing speed and executive functions measured with the computerised Cambridge Neuropsychological Test Automated Battery (CANTAB). Assessments were performed at baseline, seven and ninety days. At first interim analysis, following recruitment of 140 participants, the trial was suspended. We found that the mean (95%CI) changes of scores for episodic memory were in the Pocock futility boundaries. Decision making/processing speed did not differ either between groups (P > 0.182). But for executive functions at seven days, the mean number (95% CI) of problems successfully solved and the number of correct box choices made was higher in the N2O group, P = 0.029. N2O with the limitations of an interim analysis appears to have no harmful effect on cognitive functions (memory/processing speed). It may improve the early recovery process of executive functions. This preliminary finding warrants further investigations.
format	article
author	Guy Haller Matthew T. V. Chan Christophe Combescure Ursula Lopez Isabelle Pichon Marc Licker Roxane Fournier Paul Myles
author_facet	Guy Haller Matthew T. V. Chan Christophe Combescure Ursula Lopez Isabelle Pichon Marc Licker Roxane Fournier Paul Myles
author_sort	Guy Haller
title	The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
title_short	The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
title_full	The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
title_fullStr	The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
title_full_unstemmed	The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)
title_sort	international enigma-ii substudy on postoperative cognitive disorders (isep)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2135068b5f3a4e048e880ef43b129637
work_keys_str_mv	AT guyhaller theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT matthewtvchan theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT christophecombescure theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT ursulalopez theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT isabellepichon theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT marclicker theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT roxanefournier theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT paulmyles theinternationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT guyhaller internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT matthewtvchan internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT christophecombescure internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT ursulalopez internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT isabellepichon internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT marclicker internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT roxanefournier internationalenigmaiisubstudyonpostoperativecognitivedisordersisep AT paulmyles internationalenigmaiisubstudyonpostoperativecognitivedisordersisep
_version_	1718378026730782720

The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)

Ejemplares similares