Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essentia...

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Autores principales:	Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
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spelling	oai:doaj.org-article:2135b8948a994dbda344f75d21b684fb2021-12-02T17:32:09ZMolecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire10.1038/s41467-019-08906-72041-1723https://doaj.org/article/2135b8948a994dbda344f75d21b684fb2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08906-7https://doaj.org/toc/2041-1723For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.Jinghua LuFrançois Van LaethemAbhisek BhattacharyaMarco CraveiroIngrid SabaJonathan ChuNicholas C. LoveAnastasia TikhonovaSergei RadaevXiaoping SunAnnette KoTomer ArnonEric ShifrutNir FriedmanNan-Ping WengAlfred SingerPeter D. SunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinghua Lu François Van Laethem Abhisek Bhattacharya Marco Craveiro Ingrid Saba Jonathan Chu Nicholas C. Love Anastasia Tikhonova Sergei Radaev Xiaoping Sun Annette Ko Tomer Arnon Eric Shifrut Nir Friedman Nan-Ping Weng Alfred Singer Peter D. Sun Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
description	For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.
format	article
author	Jinghua Lu François Van Laethem Abhisek Bhattacharya Marco Craveiro Ingrid Saba Jonathan Chu Nicholas C. Love Anastasia Tikhonova Sergei Radaev Xiaoping Sun Annette Ko Tomer Arnon Eric Shifrut Nir Friedman Nan-Ping Weng Alfred Singer Peter D. Sun
author_facet	Jinghua Lu François Van Laethem Abhisek Bhattacharya Marco Craveiro Ingrid Saba Jonathan Chu Nicholas C. Love Anastasia Tikhonova Sergei Radaev Xiaoping Sun Annette Ko Tomer Arnon Eric Shifrut Nir Friedman Nan-Ping Weng Alfred Singer Peter D. Sun
author_sort	Jinghua Lu
title	Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
title_short	Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
title_full	Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
title_fullStr	Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
title_full_unstemmed	Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
title_sort	molecular constraints on cdr3 for thymic selection of mhc-restricted tcrs from a random pre-selection repertoire
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
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Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

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