The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate

We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins. We have found sequential administration of small doses of copper sulfate provided the formation...

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Autores principales:	Anatoly I. Bozhkov, Vadim I. Sidorov, Omar K. Alboqai, Rustam A. Akzhyhitov, Natalia I. Kurguzova, Anatoly B. Malyshev, Mohammad Ali Yousef Albegai, Taras Yu. Gromovoi
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Copper resistance Age Metallothioneins Redox system Medicine R
Acceso en línea:	https://doaj.org/article/2137e7f183914f928b82c397a34d2fbc
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spelling	oai:doaj.org-article:2137e7f183914f928b82c397a34d2fbc2021-11-26T04:37:23ZThe role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate2468-501110.1016/j.tma.2021.11.001https://doaj.org/article/2137e7f183914f928b82c397a34d2fbc2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468501121000067https://doaj.org/toc/2468-5011We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins. We have found sequential administration of small doses of copper sulfate provided the formation of resistance to subsequent lethal doses of copper sulfate. Age-dependent differences in the adaptive response match with the difference in the metallothioneins content in liver cells. In this case of adaptation formation, there was not only an increase in metallothioneins, but also a change in the intracellular distribution of copper ions. We revealed that a multiple increase in copper ions in mitochondria and endoplasmic reticulum of liver cells was accompanied by a slight decrease in the activity of antioxidant enzymes included in their composition. It has been suggested that metallothioneins are involved not only in the accumulation and retention of copper ions, but also in active inter-protein swap. Age-dependent differences in resistance, adaptability and long-term effects of copper ions are due to differences in the metabolic systems of copper metabolism before the toxic doses administration of copper sulfate, i.e. difference in initial states.Anatoly I. BozhkovVadim I. SidorovOmar K. AlboqaiRustam A. AkzhyhitovNatalia I. KurguzovaAnatoly B. MalyshevMohammad Ali Yousef AlbegaiTaras Yu. GromovoiKeAi Communications Co., Ltd.articleCopper resistanceAgeMetallothioneinsRedox systemMedicineRENTranslational Medicine of Aging, Vol 5, Iss , Pp 62-74 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Copper resistance Age Metallothioneins Redox system Medicine R
spellingShingle	Copper resistance Age Metallothioneins Redox system Medicine R Anatoly I. Bozhkov Vadim I. Sidorov Omar K. Alboqai Rustam A. Akzhyhitov Natalia I. Kurguzova Anatoly B. Malyshev Mohammad Ali Yousef Albegai Taras Yu. Gromovoi The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
description	We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins. We have found sequential administration of small doses of copper sulfate provided the formation of resistance to subsequent lethal doses of copper sulfate. Age-dependent differences in the adaptive response match with the difference in the metallothioneins content in liver cells. In this case of adaptation formation, there was not only an increase in metallothioneins, but also a change in the intracellular distribution of copper ions. We revealed that a multiple increase in copper ions in mitochondria and endoplasmic reticulum of liver cells was accompanied by a slight decrease in the activity of antioxidant enzymes included in their composition. It has been suggested that metallothioneins are involved not only in the accumulation and retention of copper ions, but also in active inter-protein swap. Age-dependent differences in resistance, adaptability and long-term effects of copper ions are due to differences in the metabolic systems of copper metabolism before the toxic doses administration of copper sulfate, i.e. difference in initial states.
format	article
author	Anatoly I. Bozhkov Vadim I. Sidorov Omar K. Alboqai Rustam A. Akzhyhitov Natalia I. Kurguzova Anatoly B. Malyshev Mohammad Ali Yousef Albegai Taras Yu. Gromovoi
author_facet	Anatoly I. Bozhkov Vadim I. Sidorov Omar K. Alboqai Rustam A. Akzhyhitov Natalia I. Kurguzova Anatoly B. Malyshev Mohammad Ali Yousef Albegai Taras Yu. Gromovoi
author_sort	Anatoly I. Bozhkov
title	The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
title_short	The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
title_full	The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
title_fullStr	The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
title_full_unstemmed	The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
title_sort	role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/2137e7f183914f928b82c397a34d2fbc
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The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate

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