Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery

Abstract We investigated the sensitivity, specificity and safety of ergonovine provocation test of radial artery in the diagnosis of coronary artery spasm (CAS). The patients who came to our hospital for chest pain from January to June 2020 as well as had coronary stenosis < 50% and no radial art...

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Autores principales:	Ye-fei Li, Yu Zhang, Liang Chen, Kou-long Zheng, Hui-he Lu, Zhen-qiang Sheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21382ac557534b928898061071ec2f83
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spelling	oai:doaj.org-article:21382ac557534b928898061071ec2f832021-12-02T13:30:10ZDiagnosis of coronary artery spasm by ergonovine provocation test of radial artery10.1038/s41598-021-83356-02045-2322https://doaj.org/article/21382ac557534b928898061071ec2f832021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83356-0https://doaj.org/toc/2045-2322Abstract We investigated the sensitivity, specificity and safety of ergonovine provocation test of radial artery in the diagnosis of coronary artery spasm (CAS). The patients who came to our hospital for chest pain from January to June 2020 as well as had coronary stenosis < 50% and no radial artery stenosis, were enrolled in this study. These patients were divided into CAS group and control group after intracoronary ergonovine provocation test. All patients underwent ergonovine provocation test of radial artery, the inner diameter (D0 and D1) and the peak systolic velocities (PSV0 and PSV1) of the radial artery were measured by ultrasound before and after ergonovine provocation. The predictive value of ergonovine provocation test of radial artery for the diagnosis of CAS was analyzed using receiver operator characteristic (ROC) curve. There were 19 patients in the CAS group and 28 patients in the control group. Low density lipoprotein cholesterol and smoking rate were significantly higher in the CAS group than in the control group (all P < 0.05), but there were no significant differences in other items (P > 0.05) between the two groups. In the ergonovine provocation test of radial artery, degree of radial artery stenosis was significantly higher in the CAS group [41.50% (35.60%, 50.00%)] than in the control group [11.25% (5.15%, 23.00%)] (P = 0.000), but there were no siginificant differences in D0, PSV0 and PSV1 between the two groups (P > 0.05). The area under ROC curve of ergonovine (120 µg) provocation test of radial artery for the diagnosis of CAS was 0.912 with 95%CI: 0.792–0.975, P = 0.001, cut-off of 31%, specificity of 92.86% and sensitivity of 84.21%. The ergonovine (120 µg) provocation test of radial artery did not cause any adverse reactions. We concluded that the ergonovine provocation test of radial artery has high sensitivity, specificity and safety in the diagnosis of CAS.Ye-fei LiYu ZhangLiang ChenKou-long ZhengHui-he LuZhen-qiang ShengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ye-fei Li Yu Zhang Liang Chen Kou-long Zheng Hui-he Lu Zhen-qiang Sheng Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
description	Abstract We investigated the sensitivity, specificity and safety of ergonovine provocation test of radial artery in the diagnosis of coronary artery spasm (CAS). The patients who came to our hospital for chest pain from January to June 2020 as well as had coronary stenosis < 50% and no radial artery stenosis, were enrolled in this study. These patients were divided into CAS group and control group after intracoronary ergonovine provocation test. All patients underwent ergonovine provocation test of radial artery, the inner diameter (D0 and D1) and the peak systolic velocities (PSV0 and PSV1) of the radial artery were measured by ultrasound before and after ergonovine provocation. The predictive value of ergonovine provocation test of radial artery for the diagnosis of CAS was analyzed using receiver operator characteristic (ROC) curve. There were 19 patients in the CAS group and 28 patients in the control group. Low density lipoprotein cholesterol and smoking rate were significantly higher in the CAS group than in the control group (all P < 0.05), but there were no significant differences in other items (P > 0.05) between the two groups. In the ergonovine provocation test of radial artery, degree of radial artery stenosis was significantly higher in the CAS group [41.50% (35.60%, 50.00%)] than in the control group [11.25% (5.15%, 23.00%)] (P = 0.000), but there were no siginificant differences in D0, PSV0 and PSV1 between the two groups (P > 0.05). The area under ROC curve of ergonovine (120 µg) provocation test of radial artery for the diagnosis of CAS was 0.912 with 95%CI: 0.792–0.975, P = 0.001, cut-off of 31%, specificity of 92.86% and sensitivity of 84.21%. The ergonovine (120 µg) provocation test of radial artery did not cause any adverse reactions. We concluded that the ergonovine provocation test of radial artery has high sensitivity, specificity and safety in the diagnosis of CAS.
format	article
author	Ye-fei Li Yu Zhang Liang Chen Kou-long Zheng Hui-he Lu Zhen-qiang Sheng
author_facet	Ye-fei Li Yu Zhang Liang Chen Kou-long Zheng Hui-he Lu Zhen-qiang Sheng
author_sort	Ye-fei Li
title	Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
title_short	Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
title_full	Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
title_fullStr	Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
title_full_unstemmed	Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
title_sort	diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21382ac557534b928898061071ec2f83
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Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery

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