Senescence and entrenchment in evolution of amino acid sites

Amino acid propensities at sites change over evolutionary time, due to epistatically interacting sites or environmental changes. Here, the authors develop an approach to distinguish between these, and model the fitness dynamics of each, then annotate indicative sites in vertebrate and insect genomes...

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Autores principales:	A. V. Stolyarova, E. Nabieva, V. V. Ptushenko, A. V. Favorov, A. V. Popova, A. D. Neverov, G. A. Bazykin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/213aa9e55536498986b528f274267ef7
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spelling	oai:doaj.org-article:213aa9e55536498986b528f274267ef72021-12-02T18:50:53ZSenescence and entrenchment in evolution of amino acid sites10.1038/s41467-020-18366-z2041-1723https://doaj.org/article/213aa9e55536498986b528f274267ef72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18366-zhttps://doaj.org/toc/2041-1723Amino acid propensities at sites change over evolutionary time, due to epistatically interacting sites or environmental changes. Here, the authors develop an approach to distinguish between these, and model the fitness dynamics of each, then annotate indicative sites in vertebrate and insect genomes.A. V. StolyarovaE. NabievaV. V. PtushenkoA. V. FavorovA. V. PopovaA. D. NeverovG. A. BazykinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. V. Stolyarova E. Nabieva V. V. Ptushenko A. V. Favorov A. V. Popova A. D. Neverov G. A. Bazykin Senescence and entrenchment in evolution of amino acid sites
description	Amino acid propensities at sites change over evolutionary time, due to epistatically interacting sites or environmental changes. Here, the authors develop an approach to distinguish between these, and model the fitness dynamics of each, then annotate indicative sites in vertebrate and insect genomes.
format	article
author	A. V. Stolyarova E. Nabieva V. V. Ptushenko A. V. Favorov A. V. Popova A. D. Neverov G. A. Bazykin
author_facet	A. V. Stolyarova E. Nabieva V. V. Ptushenko A. V. Favorov A. V. Popova A. D. Neverov G. A. Bazykin
author_sort	A. V. Stolyarova
title	Senescence and entrenchment in evolution of amino acid sites
title_short	Senescence and entrenchment in evolution of amino acid sites
title_full	Senescence and entrenchment in evolution of amino acid sites
title_fullStr	Senescence and entrenchment in evolution of amino acid sites
title_full_unstemmed	Senescence and entrenchment in evolution of amino acid sites
title_sort	senescence and entrenchment in evolution of amino acid sites
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/213aa9e55536498986b528f274267ef7
work_keys_str_mv	AT avstolyarova senescenceandentrenchmentinevolutionofaminoacidsites AT enabieva senescenceandentrenchmentinevolutionofaminoacidsites AT vvptushenko senescenceandentrenchmentinevolutionofaminoacidsites AT avfavorov senescenceandentrenchmentinevolutionofaminoacidsites AT avpopova senescenceandentrenchmentinevolutionofaminoacidsites AT adneverov senescenceandentrenchmentinevolutionofaminoacidsites AT gabazykin senescenceandentrenchmentinevolutionofaminoacidsites
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Senescence and entrenchment in evolution of amino acid sites

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