Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment

Background: In the present study, we aimed to investigate the effects of probucol on aging-related hippocampus-dependent cognitive impairment and explore the potential mechanisms. Methods: D-galactose (100 mg/kg, once daily for 6 weeks) was subcutaneously injected to induce aging in mice. Then the m...

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Autores principales:	Yaru Xie, Anni Song, Yuting Zhu, Anni Jiang, Wenpeng Peng, Chun Zhang, Xianfang Meng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	D-galactose Probucol Aging Hippocampus Learning and memory Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/21440cd05fdf41cebe48d19e2031da17
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spelling	oai:doaj.org-article:21440cd05fdf41cebe48d19e2031da172021-11-14T04:29:01ZEffects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment0753-332210.1016/j.biopha.2021.112266https://doaj.org/article/21440cd05fdf41cebe48d19e2031da172021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010507https://doaj.org/toc/0753-3322Background: In the present study, we aimed to investigate the effects of probucol on aging-related hippocampus-dependent cognitive impairment and explore the potential mechanisms. Methods: D-galactose (100 mg/kg, once daily for 6 weeks) was subcutaneously injected to induce aging in mice. Then the mice were administered with probucol or vehicle once a day for 2 weeks. The hippocampus-related cognition was evaluated with Morris water maze test, novel object recognition test, and contextual fear conditioning test. Moreover, synaptic plasticity was assessed, and RNA-sequencing was applied to further explore the molecular mechanisms. Results: Aging mice induced by D-galactose showed conspicuous learning and memory impairment, which was significantly ameliorated by probucol. Meanwhile, probucol enhanced the spine density and dendritic branches, improved long-term potentiation, and increased the expression of PSD95 of aging mice. Probucol regulated 70 differentially expressed genes compared to D-galactose group, of which 38 genes were upregulated and 32 genes were downregulated. At last, RNA-sequencing results were verified by quantitative reverse transcription-polymerase chain reaction. Conclusions: Probucol improved learning and memory in aging mice through enhancing synaptic plasticity and regulating gene expression, indicating the potential application of probucol to prevent and treat aging-related disorders.Yaru XieAnni SongYuting ZhuAnni JiangWenpeng PengChun ZhangXianfang MengElsevierarticleD-galactoseProbucolAgingHippocampusLearning and memoryTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112266- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	D-galactose Probucol Aging Hippocampus Learning and memory Therapeutics. Pharmacology RM1-950
spellingShingle	D-galactose Probucol Aging Hippocampus Learning and memory Therapeutics. Pharmacology RM1-950 Yaru Xie Anni Song Yuting Zhu Anni Jiang Wenpeng Peng Chun Zhang Xianfang Meng Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
description	Background: In the present study, we aimed to investigate the effects of probucol on aging-related hippocampus-dependent cognitive impairment and explore the potential mechanisms. Methods: D-galactose (100 mg/kg, once daily for 6 weeks) was subcutaneously injected to induce aging in mice. Then the mice were administered with probucol or vehicle once a day for 2 weeks. The hippocampus-related cognition was evaluated with Morris water maze test, novel object recognition test, and contextual fear conditioning test. Moreover, synaptic plasticity was assessed, and RNA-sequencing was applied to further explore the molecular mechanisms. Results: Aging mice induced by D-galactose showed conspicuous learning and memory impairment, which was significantly ameliorated by probucol. Meanwhile, probucol enhanced the spine density and dendritic branches, improved long-term potentiation, and increased the expression of PSD95 of aging mice. Probucol regulated 70 differentially expressed genes compared to D-galactose group, of which 38 genes were upregulated and 32 genes were downregulated. At last, RNA-sequencing results were verified by quantitative reverse transcription-polymerase chain reaction. Conclusions: Probucol improved learning and memory in aging mice through enhancing synaptic plasticity and regulating gene expression, indicating the potential application of probucol to prevent and treat aging-related disorders.
format	article
author	Yaru Xie Anni Song Yuting Zhu Anni Jiang Wenpeng Peng Chun Zhang Xianfang Meng
author_facet	Yaru Xie Anni Song Yuting Zhu Anni Jiang Wenpeng Peng Chun Zhang Xianfang Meng
author_sort	Yaru Xie
title	Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
title_short	Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
title_full	Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
title_fullStr	Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
title_full_unstemmed	Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
title_sort	effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/21440cd05fdf41cebe48d19e2031da17
work_keys_str_mv	AT yaruxie effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT annisong effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT yutingzhu effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT annijiang effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT wenpengpeng effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT chunzhang effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment AT xianfangmeng effectsandmechanismsofprobucolonagingrelatedhippocampusdependentcognitiveimpairment
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Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment

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