Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice

The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the lo...

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Autores principales:	Rémi Bos, Benoît Drouillas, Mouloud Bouhadfane, Emilie Pecchi, Virginie Trouplin, Sergiy M. Korogod, Frédéric Brocard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/214612d1787d4019a823b0b8efb12a75
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spelling	oai:doaj.org-article:214612d1787d4019a823b0b8efb12a752021-11-28T12:32:14ZTrpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice10.1038/s41467-021-27113-x2041-1723https://doaj.org/article/214612d1787d4019a823b0b8efb12a752021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27113-xhttps://doaj.org/toc/2041-1723The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the locomotor output.Rémi BosBenoît DrouillasMouloud BouhadfaneEmilie PecchiVirginie TrouplinSergiy M. KorogodFrédéric BrocardNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rémi Bos Benoît Drouillas Mouloud Bouhadfane Emilie Pecchi Virginie Trouplin Sergiy M. Korogod Frédéric Brocard Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
description	The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the locomotor output.
format	article
author	Rémi Bos Benoît Drouillas Mouloud Bouhadfane Emilie Pecchi Virginie Trouplin Sergiy M. Korogod Frédéric Brocard
author_facet	Rémi Bos Benoît Drouillas Mouloud Bouhadfane Emilie Pecchi Virginie Trouplin Sergiy M. Korogod Frédéric Brocard
author_sort	Rémi Bos
title	Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
title_short	Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
title_full	Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
title_fullStr	Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
title_full_unstemmed	Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
title_sort	trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/214612d1787d4019a823b0b8efb12a75
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Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice

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